Mesothelioma in immigrants from Turkey: Genes have a minor role - 21/09/21
![](/templates/common/images/mail.png)
Abstract |
Objective |
To examine the incidence and epidemiology of malignant mesothelioma in immigrants from Karain where there is an extraordinarily high incidence of mesothelioma, Cappadocia, Turkey, to Stockholm, Sweden, and their children over 20 years of age born in Stockholm, i.e. two genetically similar populations with and without erionite exposure.
Methods |
This survey was conducted as a retrospective cohort study. Standardized average annual mesothelioma incidence rates (AAMIRs) and mesothelioma standardized incidence ratio (mSIR) were calculated. Cox regression analysis was used to determine the importance of different factors related to mesothelioma risk.
Results |
The cohort consisted of 337 people, 203 of whom were born and/or lived in Karain before immigrating to Sweden (erionite-exposed), and 134 who were born in Stockholm (erionite-unexposed). There were 69 deaths, 42 (61%) due to mesothelioma, and two patients with the disease who were still alive. Of these 44 patients, 22 were men. All mesothelioma patients were in the erionite-exposed group. In the age group 30–49 years, mesothelioma developed in 11 of 38 (29%) with erionite exposure, while there were no cases among 86 persons in the non-exposed group. For men, the AAMIR was 253.9 per 100,000 persons in the whole cohort, and for women, it was 350.9. The mSIR was 71.9 for men and 393.1 for women. Exposure to erionite exceeding 20 years and age over 40 years were associated with increased mesothelioma risk.
Conclusion |
Exposure to erionite is the leading cause of mesothelioma in Karain villagers, and genetic factors are probably of minor importance.
Le texte complet de cet article est disponible en PDF.Highlights |
• | People born in Karain have a very high risk of mesothelioma. |
• | People from Karain but not born there have a very low risk of mesothelioma. |
• | Thus genetics have a minor role for risk of mesothelioma. |
• | The results of this study support the gene-environment interaction thesis. |
• | Genetic factors can only be effective in the development of mesothelioma in those who have asbestos or erionite exposure. |
Keywords : Mesothelioma, Epidemiology, Erionite, Environmental exposure, Genetic
Plan
Vol 186
Article 106527- septembre 2021 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?