Transmission of SARS-CoV-2 in the household setting: A prospective cohort study in children and adults in England - 21/09/21
, Pauline A. Waight a , Nick J. Andrews b , Kelsey McOwat a , Kevin E. Brown a , Katja Höschler c , Samreen Ijaz c , Louise Letley a , Donna Haskins a , Mary Sinnathamby a , Hannah Cuthbertson d , Bassam Hallis d , Vaishnavi Parimalanathan e , Simon de Lusignan e , Jamie Lopez-Bernal a
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Summary |
Objectives |
To measure secondary attack rates (SARs) in prospectively followed household contacts of paediatric and adult cases of SARS-CoV-2 infection in England.
Methods |
Self-taken nasal swabs from household contacts of PCR confirmed cases of COVID-19 and blood samples on day 35 were tested for evidence of infection with SARS-CoV-2 virus.
Results |
The secondary attack rate (SAR) among 431 contacts of 172 symptomatic index cases was 33% (95% confidence intervals [CI] 25–40) and was lower from primary cases without respiratory symptoms, 6% (CI 0–14) vs 37% (CI 29–45), p = 0.030. The SAR from index cases <11 years was 25% (CI 12–38). SARs ranged from 16% (4–28) in contacts <11 years old to 36% (CI 28–45) in contacts aged 19–54 years (p = 0.119). The proportion infected who developed symptoms (78%) was similar by age (p = 0.44) though <19 year olds had fewer mean number of symptoms than adults (p = 0.001) and fewer reported loss of sense of taste or smell (p = 0.0001).
Conclusions |
: There are high risks of transmission of SARS-CoV-2 virus in the home, including those where infection is introduced by a child. The risk of children acquiring infection was lower than that in adults and fewer developed typical symptoms of Covid-19 infection.
Le texte complet de cet article est disponible en PDF.Keywords : SARS-CoV-2 transmission, Secondary attack rates by age, Households
Plan
Vol 83 - N° 4
P. 483-489 - octobre 2021 Retour au numéro
Article précédent
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