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Large underreporting of COPD as cause of death-results from a population-based cohort study - 21/09/21

Doi : 10.1016/j.rmed.2021.106518 
Anne Lindberg a, Lina Lindberg a, Sami Sawalha a, Ulf Nilsson a, Caroline Stridsman a, Bo Lundbäck b, Helena Backman c,
a Department of Public Health and Clinical Medicine, Section of Medicine, Umeå University, Umeå, Sweden 
b Krefting Krefting Research Centre, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden 
c Department of Public Health and Clinical Medicine, Section of Sustainable Health/the OLIN Unit, Umeå University, Umeå, Sweden 

Corresponding author. Department of Public Health and Clinical Medicine, Section of Sustainable Health/the OLN unit Umeå university, Sweden.Department of Public Health and Clinical MedicineSection of Sustainable Health/the OLN unit Umeå universitySweden

Abstract

Background

In 2019, WHO estimated COPD to be the third leading cause of death in the world. However, COPD is probably underestimated as cause of death due to the well-known under-diagnosis.

Aim

To evaluate the proportion of and factors associated with COPD recorded as cause of death in a long-term follow-up of a population-based COPD cohort.

Methods

The study population includes all individuals (n = 551) with COPD defined as chronic airway obstruction (post-bronchodilator FEV1/FVC<0.70) + respiratory symptoms identified after re-examinations of four population-based cohorts. Mortality and underlying or contributing cause of death following ICD-10 classification were collected from the Swedish National Board of Health and Welfares register from date of examination in 2002–04 until 2016.

Results

The study sample consisted of 32.3% GOLD 1, 55.9% GOLD 2, and 11.8% GOLD 3–4. The mean follow-up time was 10.3 (SD3.77) years and the cumulative mortality 45.0%. COPD (ICD-10 J43-J44) was recorded on 28.2% (n = 70) of the death certificates (11.1%, 25.7% and 57.1% by GOLD stage), whereof n = 35 had COPD recorded as underlying and n = 35 as contributing cause of death. To have COPD recorded as cause of death was independently associated with ex- and current smoking and a self-reported physician diagnosis of COPD, while male sex, overweight/obesity and higher FEV1% of predicted associated with the absence.

Conclusions

COPD was largely underreported cause of death. Even among those with severe/very severe disease, COPD was only mentioned on 57.1% of the death certificates.

Le texte complet de cet article est disponible en PDF.

Highlights

Only 28.2% had COPD recorded as either underlying or contributing cause of death.
In those having COPD recorded as cause of death, it was the underlying cause in 50%.
Severe COPD was not reported even as contributing cause of death in 43%.
Under-diagnosis and -recognition of COPD contribute to the underreporting.

Le texte complet de cet article est disponible en PDF.

Keywords : Epidemiology, Chronic obstructive pulmonary disease, Mortality, Risk factor, Physician diagnosis


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© 2021  The Author(s). Publié par Elsevier Masson SAS. Tous droits réservés.
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Vol 186

Article 106518- septembre 2021 Retour au numéro
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