Epidemiology and outcomes of primary pediatric lung malignancies: Updates from the SEER database - 16/09/21
, Devashis Mukherjee b, Yu Wang c, Ruta Brazauskas c, Ariel A. Nelson d, Chandler S. Cortina eAbstract |
Background |
Primary pediatric lung malignancies are rare tumors. We provide an updated analysis of the epidemiology and prognosis of these tumors since the last SEER series published in 2009.
Methods |
The SEER 18 database from 1975 to 2016 was analyzed for patients ages 0–19 years with primary lung and/or bronchus neoplasms.
Results |
348 patients met inclusion criteria. The majority were white and ≥12 years of age. The most common histologies were neuroendocrine (41.4%) and blastoma (16.4%). 75.4% of patients had local-regional disease and 81.4% underwent surgery. Significant differences between histologies were seen for age, year at diagnosis, tumor laterality and location, stage, and treatment type. Median survival was 36.6 years (95% CI 33.3–37.4). Blastoma (HR 3.47) and squamous cell (HR 6.26) carried a significantly higher risk of death than neuroendocrine cancer diagnosis.
Conclusion |
Primary pediatric lung malignancies are rare, long-term survival is favorable but histology-dependent. Surgery continues to be an important treatment modality.
Le texte complet de cet article est disponible en PDF.Highlights |
• | Primary pediatric lung tumors are rare making study of their epidemiology difficult. |
• | Outcomes are dependent on tumor characteristics, patient demographics and treatment. |
• | Overall survival is favorable, but significantly dependent on tumor histology. |
• | Blastoma and squamous cell carcinoma still protend a poor prognosis. |
• | Better understanding of these tumors can inform treatment plans and prognosis. |
Keywords : Lung tumors, Pediatric, SEER database
Plan
Vol 222 - N° 4
P. 861-866 - octobre 2021 Retour au numéro
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