Sex differences in long-term outcomes after traumatic injury: A mediation analysis - 16/09/21
Abstract |
Background |
We sought to examine the association and potential mediators between sex and long-term trauma outcomes.
Methods |
Moderately-to-severely injured patients admitted to 3 level-1 trauma centers were contacted between 6 and 12-months post-injury to assess for functional limitations, use of pain medications, and posttraumatic stress disorder (PTSD). Multivariable adjusted regression analyses were used to compare long-term outcomes by sex. Potential mediators of the relationship between sex and outcomes was explored using mediation analysis.
Results |
2607 patients were followed, of which 45% were female. Compared to male, female patients were more likely to have functional limitations (OR: 1.45; 95% CI: 1.31–1.60), take pain medications (OR: 1.17; 95% CI: 1.02–1.38), and screen positive for PTSD (OR: 1.60; 95% CI: 1.46–1.76) post-injury. Age, extremity injury, previous psychiatric illness, and pre-injury unemployment, partially mediated the effect of female sex on long-term outcomes.
Conclusions |
There are significant sex differences in long-term trauma outcomes, which are partially driven by patient and injury-related factors.
Le texte complet de cet article est disponible en PDF.Highlights |
• | Compared to males, female patients are more likely to have worse outcomes 6–12 months post-injury. |
• | Sex differences in long-term trauma outcomes are partially driven by patient and injury-related factors. |
• | Mediation analysis is a novel and informative methodology for the study of sex disparities in post-injury outcomes. |
Keywords : Sex disparities, Injury, PTSD, Pain, Functional status
Plan
☆ | The present original work was funded by the Center for Surgery and Public Health own resources. |
Vol 222 - N° 4
P. 842-848 - octobre 2021 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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