Sex differences in long-term outcomes after traumatic injury: A mediation analysis - 16/09/21
, Mohamad El Moheb b, Anju Ranjit c, Christina Weed d, Karen Brasel e, George Kasotakis f, Haytham M.A. Kaafarani b, George Velmahos b, Deepika Nehra g, Adil H. Haider a, h, Molly Jarman a, Ali Salim aAbstract |
Background |
We sought to examine the association and potential mediators between sex and long-term trauma outcomes.
Methods |
Moderately-to-severely injured patients admitted to 3 level-1 trauma centers were contacted between 6 and 12-months post-injury to assess for functional limitations, use of pain medications, and posttraumatic stress disorder (PTSD). Multivariable adjusted regression analyses were used to compare long-term outcomes by sex. Potential mediators of the relationship between sex and outcomes was explored using mediation analysis.
Results |
2607 patients were followed, of which 45% were female. Compared to male, female patients were more likely to have functional limitations (OR: 1.45; 95% CI: 1.31–1.60), take pain medications (OR: 1.17; 95% CI: 1.02–1.38), and screen positive for PTSD (OR: 1.60; 95% CI: 1.46–1.76) post-injury. Age, extremity injury, previous psychiatric illness, and pre-injury unemployment, partially mediated the effect of female sex on long-term outcomes.
Conclusions |
There are significant sex differences in long-term trauma outcomes, which are partially driven by patient and injury-related factors.
Le texte complet de cet article est disponible en PDF.Highlights |
• | Compared to males, female patients are more likely to have worse outcomes 6–12 months post-injury. |
• | Sex differences in long-term trauma outcomes are partially driven by patient and injury-related factors. |
• | Mediation analysis is a novel and informative methodology for the study of sex disparities in post-injury outcomes. |
Keywords : Sex disparities, Injury, PTSD, Pain, Functional status
Plan
| ☆ | The present original work was funded by the Center for Surgery and Public Health own resources. |
Vol 222 - N° 4
P. 842-848 - octobre 2021 Retour au numéro
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