CRISPR: History and perspectives to the future - 03/09/21
, S. Rajcaniova b, P. Munteanu c, S. Dzacovska d, L. Demkova aBienvenue sur EM-consulte, la référence des professionnels de santé.
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Abstract |
This review summarizes the information about the history and future of the CRISPR/Cas9 method. Genome editing can be perceived as a group of technologies that allow scientists to change the DNA of an organism. These technologies involve the deletion, insertion, or modification of the genome at a specific site in a DNA sequence. Gene therapy in humans has a perspective to be used to eliminate the gene responsible for a particular genetic disorder. The review focuses on the key elements of this promising method and the possibility of its application in the treatment of cancer and genetic diseases.
Le texte complet de cet article est disponible en PDF.Graphical Abstract |
Highlights |
• | Classification and properties of different types of Cas proteins. |
• | CRISPR system mechanism of action and its main components: sgRNA, PAM and Cas protein. |
• | Delivery methods of CRISPR therapeutic components to the patient's body. |
• | New progressive methods of cancer therapy and genetic modification of cells by CRISPR. |
• | How to overcome technological issues in genome editing via CRISPR. |
Keywords : CRISPR, Gene engineering, Cas endonucleases, On or off-targets effects
Plan
Vol 141
Article 111917- septembre 2021 Retour au numéro
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