Energy metabolism in major depressive disorder: Recent advances from omics technologies and imaging - 03/09/21
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
| pages | 11 |
| Iconographies | 3 |
| Vidéos | 0 |
| Autres | 0 |
Abstract |
Major depressive disorder (MDD) is a serious psychiatric disorder that associated with high rate of disability and increasing suicide rate, and the pathogenesis is still unclear. Many researches showed that the energy metabolism of patients with depression is impaired, which may be the direction of depression treatment. In this review, we focus on the "omics" technologies such as genomics, proteomics, transcriptomics and metabolomics, as well as imaging, and the progress on energy metabolism of MDD. These findings indicate that abnormal energy metabolism is one of the important mechanisms for the occurrence and development of depression. Although the research on various mechanisms of depression is still ongoing, the rapid development of new technologies and the joint use of various technologies will help to clarify the pathogenesis of depression and explore efficient diagnosis and treatment methods.
Le texte complet de cet article est disponible en PDF.Graphical Abstract |
Highlights |
• | Energy metabolism may play a vital role in depression. |
• | Omics technologies provide a possibility for discovering potential biomarkers. |
• | Imaging technology reveals the abnormal brain metabolism. |
Abbreviations : 2-DE, 2D DIGE, 5-HT, ACC, AK1, ATP, BCAAs, CKB, CMS, CORT, CSDS, CSF, CUMS, ELISA, FDA, FSL, GABA, GAL, GAPDH, GC-MS, GC-TOFMS, HPA, HPLC, iTRAQ, LC-MS, LDH, LPS, MALDI-TOF-MS, ME, MDD, MRI, MRS, MyD-88, NAA, NADH, NADPH, Nduf, NE, NF-κB, NMR, pAMPK, PBMCs, PCr, PET, PF, PFC, PFK, PK, RL, ROS, RT-PCR, TCA, TLR4, TNF-α, TPI1, Ucn 3, UPLC-QTOFMS, Uqcc, VGLUT1
Keywords : Major depressive disorder, Energy metabolism, "Omics" technologies, Imaging
Plan
Vol 141
Article 111869- septembre 2021 Retour au numéro
Article précédent
- The role of Hypoxia-Inducible Factor-1alpha and its signaling in melanoma
- Mohammad Malekan, Mohammad Ali Ebrahimzadeh, Fateme Sheida
- Emerging application of metabolomics on Chinese herbal medicine for depressive disorder
- Xinyi Gu, Xingyuan Gao, Jieyi Cheng, Chenyi Xia, Ying Xu, Li Yang, Mingmei Zhou
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’achat d’article à l’unité est indisponible à l’heure actuelle.
Déjà abonné à cette revue ?