Dual role of microRNA-1297 in the suppression and progression of human malignancies - 03/09/21
, Forogh Mohammadi f, ⁎ Bienvenue sur EM-consulte, la référence des professionnels de santé.
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Abstract |
MicroRNAs (miRNAs) are endogenous, non-coding, single-stranded and tiny RNAs that modulate several biological functions, more importantly, the pathophysiology of numerous human cancers. They are bound with target mRNAs and thereby regulate gene expression at post-transcriptional levels. MiRNAs can either trigger cancer progression as an oncogene or alleviate it as a tumor suppressor. Abnormal expression of microRNA-1297 (miR-1297) has been noticed in several human cancers suggesting a distinct role for the miRNA in tumorigenesis. More specifically, it is both up-regulated and down-regulated in various cancers suggesting that it can act as both tumor suppressor and oncogene. This review systematically highlights the different roles of miR-1297 in the pathophysiology of human cancers, explains the mechanisms underlying miR-1297-mediated tumorigenesis, and discusses its potential prognostic, diagnostic, and therapeutic importance.
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Highlights |
• | miR-1297 has a tumor-suppressive or oncogenic function in human neoplasms. |
• | MiR-1297 executes a crucial role in the pathophysiology of multiple human cancers, causing tumor progression or suppression. |
• | LncRNAs and CircRNAs can sponge the miR-1297, then reverse the effects of miR-1297 in various malignancies. |
• | MiR-1297 may be considered a novel diagnostic and prognostic biomarker; also, potentially novel promising strategy for human malignancy treatment. |
Keywords : MicroRNA-1297, Cancer, Tumor suppressor, Oncogene
Plan
Vol 141
Article 111863- septembre 2021 Retour au numéro
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