Alteration of gut microbiota in acute pancreatitis and associated therapeutic strategies - 03/09/21

Doi : 10.1016/j.biopha.2021.111850

Ying Zhu ^a,^b,^{^{1
Ying Zhu, Qixiang Mei and Yang Fu should be regarded as equivalent first authors.}}, Qixiang Mei ^a,^b,^{^{1
Ying Zhu, Qixiang Mei and Yang Fu should be regarded as equivalent first authors.}}, Yang Fu ^a,^b,^{^{1
Ying Zhu, Qixiang Mei and Yang Fu should be regarded as equivalent first authors.}}, Yue Zeng ^b,^⁎
^a Shanghai Key Laboratory of Pancreatic Disease, Shanghai JiaoTong University School of Medicine, Shanghai 201600, China
^b Department of Gastroenterology, Shanghai General Hospital, Shanghai JiaoTong University School of Medicine, Shanghai 201600, China

^⁎Correspondence to: 650 xinsongjiang road, Songjiang district, Shanghai 201600, China.650 xinsongjiang road, Songjiang districtShanghai201600China

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Abstract

Gut microbiome is considered as a crucial regulator of human health. Alteration of gut microbiome has been reported in acute pancreatitis (AP) and probably contributes to the severity of disease. Explore the precise role of gut microbiome in the pathogenesis of AP could offer new strategies to improve the clinical outcomes of AP. This review summarizes the role of gut microbiome in AP, lists possible mechanisms associated with it and offers an overview of current treatments based on gut microbiome.

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Graphical Abstract

Dysbiosis of gut microbiota during AP destroys gut homeostasis and further worsens the disease. Restoring the balance of intestinal microbiome is a promising strategy for AP.

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Highlights

•	Gut flora alters in the process of acute pancreatitis.
•	Disruption of intestinal homeostasis aggravates acute pancreatitis.
•	Modulating gut microbiota is a promising treatment for acute pancreatitis.

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Abbreviations : AMP, ANP, AP, BT, EN, FMT, ICCs, IRI, LPS, MAP, MLN, MMC, MSAP, SAP, SCFAs, SIRS

Keywords : Gut microbiome, Acute pancreatitis, Gut homeostasis, Bacterial translocation, Microbiome-based treatment

Plan

Introduction

Alteration of gut microbiome in AP

Gut microbiota in progression of AP

Possible mechanisms of gut microbial dysbiosis in AP

Gut microbial dysbiosis participates in the pathogenesis of AP

Alteration of gut bacterial metabolites during AP

Microbiota-based treatment of AP

Probiotics

Antibiotics

Fecal microbiota transplantation (FMT)

Therapies altering gut microbiome indirectly

Potential treatments

Conclusions

Funding

CRediT authorship contribution statement

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Vol 141

Article 111850- septembre 2021 Retour au numéro

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Alteration of gut microbiota in acute pancreatitis and associated therapeutic strategies - 03/09/21

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