Liposomal honokiol promotes hair growth via activating Wnt3a/β-catenin signaling pathway and down regulating TGF-β1 in C57BL/6N mice - 03/09/21
, Jinyi Chen , Feng Chen , Ce Wang , Xiaodi Guo , Can Wang , Yaqiong Fan , Yali Wang , Yichen Peng , Wenbin Li ⁎ Bienvenue sur EM-consulte, la référence des professionnels de santé.
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Abstract |
Liposomal honokiol isolated from the genus Magnolia has been found to have antiangiogenic, anti-inflammatory and antitumor properties. However, there has no report on its role in hair growth. Hair follicles are life-long cycled organelles that go through from anagen, catagen and telogen stages and are regulated by diverse signaling pathways, including Wnt/β-catenin, Notch, Epidermal growth factor (EGF) and Sonic hegehog (SHH). Wnt signals are essential for the initiation of hair follicle placode development and a new potential target of hair loss treatment. This study was designed to investigate the effect of liposomal honokiol (Lip-honokiol) on inducing hair anagen. We identified the hair grew out in advance in the shaving area of C57BL/6N mice after the treatment of liposomal honokiol (Lip-honokiol) by daily abdominal injection. We first demonstrated that Lip-Honokiol activated the Wnt3a/β-catenin pathway and downregulated the transforming growth factor-β1 (TGF-β1) to promote hair growth in mice via immunohistochemistry and immunofluorescence staining. These findings suggest that Lip-honokiol activated the Wnt/β-catenin pathway and accelerated the transfer from the telogen to anagen stage and finally promoted the hair growth.
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Highlights |
• | The Lip-honokiol was associated with the transfer of hair follicles from telogen stage to anagen stage. |
• | The Lip-honokiol accelerated the hair growth cycle by upregulating the Wnt3a/β-catenin signaling pathway. |
• | The Lip-honokiol inhibited the TGF-β1/p-smad2 signaling pathway during the anagen stage. |
• | The Lip-honokiol increased the Ki67 and p-histone H3 expression by IHC. |
Keywords : Hair growth, Liposomal honokiol, Wnt3a, β-catenin, TGF-β1, Hair cycle
Plan
Vol 141
Article 111793- septembre 2021 Retour au numéro
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