Identification of oligopeptides from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) non structural protein 8 (NSP8) and their similarities with type 1 angiotensin II receptor key sites - 03/09/21
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Abstract |
Coronavirus disease 2019 is associated with clinical symptoms including severe inflammatory syndrome and a higher expression of angiotensin II. As a pro-inflammatory mediator, the physiologic effects of angiotensin II are mediated by a G-protein coupled receptor, termed AT1R. Following binding, AT1R initiates the process of signal desensitization necessary to maintain cellular homeostasis. At the cellular level, this function occurs via the G protein-dependent signaling and the phosphorylation. We describe amino acids similarities between SARS COV-2 nonstructural protein (NSP8) which is associated with intracellular membranes and AT1R key sites. Since abnormal activation of AT1R receptor leads to a number of physiological disorders, we hypothesize that SARS COV-2 might further interfere with the angiotensin II receptor functions.
Le texte complet de cet article est disponible en PDF.Abbreviations : a.a, ACE-2, Ang II, AT1R, Cpp, Covid 19, LPS, NSP8, ORF1ab, SARS-CoV-2
Keywords : Sarscov-2, NSP8, AT1R, G protein, Peptides, Similarity angiotensin II
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Vol 141
Article 111722- septembre 2021 Retour au numéro
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