Glucose oxidase loaded Cu2+ based metal-organic framework for glutathione depletion/reactive oxygen species elevation enhanced chemotherapy - 03/09/21
, Lixin Sun a, Bei Lu a, Xi Yan a, Zhonghao Wang a, Tong Zhang b, ⁎ Bienvenue sur EM-consulte, la référence des professionnels de santé.
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Abstract |
Introduction |
The development of multidrug resistance (MDR) is a major cause for the failure of chemotherapy, which requires the aid of nanomedicine.
Methods |
Here in our study, a Cu2+ based metal-organic framework (COF) was firstly developed and employed as a carrier for the delivery of glucose oxidase (GOx) and doxorubicin (Dox) (COF/GOx/Dox) for the therapy of MDR lung cancers.
Results |
Our results showed that the GOx can catalyze glucose and produce H2O2. In the mean time, the Cu2+ can react with GSH and then transform into Cu+, which resulted in GSH depletion. Afterwards, the produced Cu+ and H2O2 trigger Fenton reaction to generate ROS to damage the redox equilibrium of cancer cells. Both effects contributed to the reverse of MDR in A549/Dox cells and finally resulted in significantly enhanced in vitro/in vivo anticancer performance.
Discussion |
The combination of glutathione depletion/reactive oxygen species elevation might be a promising strategy to enhance the efficacy of chemotherapy and reverse MDR in cancers.
Le texte complet de cet article est disponible en PDF.Graphical Abstract |
Highlight |
• | Gox and Dox loaded Cu2+ based metal-organic framework (COF/GOx/Dox) was developed. |
• | COF/GOx/Dox resulted in GSH depletion/ROS elevation in cancer cells. |
• | COF/GOx/Dox reverse MDR for better chemotherapy of A549/Dox cells. |
Keywords : Multidrug resistance, Glutathione depletion, MOF, Lung cancer therapy
Plan
Vol 141
Article 111606- septembre 2021 Retour au numéro
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