Assessment of SARS-CoV-2 testing in children during a low prevalence period (VIGIL study 1) - 02/09/21
, Stéphane Béchet a, Nathalie Blot f, Stéphanie Gorde d, Camille le Stradic g, Matthieu Come h, Robert Touitou a, i, Robert Cohen a, b, c, d, e
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Highlights |
• | From June 1 to July 31, 2020, a pediatric cross-sectional prospective, multicenter study throughout France showed a positivity rate of 1.4% (95%CI [0.9; 2.1]) for 1,553 nasopharyngeal SARS-CoV-2 RT-PCR tests. |
• | The predictive factors of positivity were age below 2 years and history of contact. |
• | In an epidemic stage with low SARS-CoV-2 circulation, sampling of children with nonspecific symptoms and without known contact is probably not relevant. |
Abstract |
Objectives |
SARS-CoV-2 induces a broad spectrum of clinical manifestations, which overlap with other viral infections very common in children. We aimed to describe the percentage of positive SARS-CoV-2 RT-PCR tests in symptomatic and asymptomatic ambulatory children and to determine the predictive factors for positivity.
Patients and Methods |
From June 1 to July 31, 2020, we conducted a cross-sectional prospective, multicenter study (13 hospital emergency units and 59 ambulatory pediatricians) throughout France. Children under 15 years of age with a prescription of nasopharyngeal SARS-CoV-2 RT-PCR test were enrolled.
Results |
Among the 1,553 RT-PCR tests, 22 were positive (1.4%; 95%CI [0.9; 2.1]). In both univariate and multivariate analyses, the predictive factors for positivity were age below 2 years (OR: 4.5 [1.6; 12.7]) and history of contact (OR: 12.3 [4.6; 32.8]).
Conclusions |
In an epidemic stage with low SARS-CoV-2 circulation, sampling of children with nonspecific symptoms and without known contact could be questioned.
Le texte complet de cet article est disponible en PDF.Keywords : SARS-CoV-2, RT-PCR, Children, Ambulatory, Clinical signs
Plan
Vol 51 - N° 6
P. 552-555 - septembre 2021 Retour au numéro
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