Latent tuberculosis co-infection is associated with heightened levels of humoral, cytokine and acute phase responses in seropositive SARS-CoV-2 infection - 26/08/21
, Nathella Pavan Kumar b, Chandrasekaran Padmapriyadarsini b, Arul Nancy a, Nandhini Selvaraj a, Kushiyasri Karunanithi b, Saravanan Munisankar a, Shrinivasa BM b, Rachel Mariam Renji a, T.C. Ambu b, Vijayalakshmi Venkataramani a, Subash Babu a
Bienvenue sur EM-consulte, la référence des professionnels de santé.
Article gratuit.
Connectez-vous pour en bénéficier!
Highlights |
• | LTBI#x002B; and seropositive for SARS-CoV-2 infected individuals were associated with elevated IgM, IgG and IgA antibody titres. |
• | LTBI#x002B; and seropositive for SARS-CoV-2 infected individuals were associated with enhanced neutralization activity. |
• | LTBI#x002B; individuals exhibited significantly elevated plasma levels of cytokines, chemokines and acute phase responses. |
• | Our study clearly indicates the impact of LTBI on the humoral and innate immune responses in SARS-CoV-2 infection. |
Summary |
Objectives |
Latent Tuberculosis infection (LTBI) is postulated to modulate immune responses and alter disease severity in SARS-CoV-2 co-infection. However, no data exist on the effect of LTBI on the immune responses in SARS-CoV-2 co-infected individuals.
Methods |
We examined the SARS-CoV-2 specific antibody responses, plasma cytokines, chemokines, acute phase proteins and growth factor levels in LTBI positive and negative individuals with SARS-CoV-2 infection.
Results |
Our results demonstrated that individuals with LTBI (LTBI+) and seropositive for SARS-CoV-2 infection were associated with elevated SARS-CoV-2 specific IgM, IgG and IgA antibodies, as well as enhanced neutralization activity compared to those negative for LTBI (LTBI-) individuals. Our results also demonstrate that LTBI+ individuals exhibited significantly higher plasma levels of IFNγ, IL-2, TNFα, IL-1α, IL-1β, IL-6, IL-12, IL-15, IL-17, IL-3, GM-CSF, IL-10, IL-25, IL-33, CCL3 and CXCL10 compared to LTBI- individuals. Finally, our results show that LTBI+ individuals exhibit significantly higher levels of C-reactive protein, alpha-2 macroglobulin, VEGF and TGFα compared to LTBI- individuals.
Conclusions |
Thus, our data clearly demonstrates that LTBI+ individuals seropositive for SARS-CoV-2 infection exhibit heightened levels of humoral, cytokine and acute phase responses compared to LTBI- individuals. Thus, LTBI is associated with modulation of antibody and cytokine responses as well as systemic inflammation in individuals seropositive for SARS-CoV-2 infection.
Le texte complet de cet article est disponible en PDF.Keywords : LTBI, SARS-CoV-2, Seropositive SARS-CoV-2, Neutralizing antibodies, Acute phase proteins, Cytokines
Plan
Vol 83 - N° 3
P. 339-346 - septembre 2021 Retour au numéro
Article précédent
- Undetected carriage explains apparent Staphylococcus aureus acquisition in a non-outbreak healthcare setting
- James R Price, Maho Yokoyama, Kevin Cole, Jonathan Sweetman, Laura Behar, Simon Stoneham, Daire Cantillon, Simon J Waddell, Jonathan Hyde, Ruhina Alam, Derrick Crook, John Paul, Martin J Llewelyn
- Risk factors for IRIS in HIV-associated Pneumocystis-pneumonia following ART initiation
- Gerrit Kann, Nils Wetzstein, Hannah Bielke, Gundolf Schuettfort, Annette E. Haberl, Timo Wolf, Claus P. Kuepper-Tetzel, Imke Wieters, Johanna Kessel, Philipp de Leuw, Markus Bickel, Pavel Khaykin, Christoph Stephan
Bienvenue sur EM-consulte, la référence des professionnels de santé.