Ventricular Repolarization Parameters and Coronary Involvement in Kawasaki Disease - 23/08/21
, Masaru Miura, MD, PhD 3, Sara Domínguez-Rodríguez 4, Elisa Fernández-Cooke, MD, PhD 5, Georgia Sarquella-Brugada, MD, PhD 6, 7, ∗, Alfredo Tagarro, MD, PhD 1, 2, 4, ∗on behalf of
the KAWA-RACE study group†
Abstract |
Objectives |
To evaluate electrocardiogram markers to predict coronary involvement in patients with Kawasaki disease by assessing measures of ventricular repolarization parameters on the 12-lead electrocardiogram.
Study design |
This cross-sectional study included 180 Spanish and Japanese patients ≤14 years of age with Kawasaki disease, with or without coronary involvement, from 2011 to 2016. We manually measured the Tp-Te/QT ratio and QTc interval (with Bazett's formula) in 12-lead electrocardiogram in the acute and recovery period and explored their potential association with coronary involvement.
Results |
No association was found between Tp-Te/QT ratio obtained manually in V5 and V6 leads and coronary involvement in the acute (V5:0.25 [IQR, 0.21-0.27] vs 0.25 [IQR, 0.20-0.27], P = .80; V6:0.24 [IQR, 0.21-0.27] vs 0.25 [IQR, 0.20-0.27], P = .86) or the recovery (V5: 0.23 [IQR, 0.20-0.25] vs 0.23 [IQR, 0.19-0.25], P = .68; V6: 0.23 [IQR, 0.20-0.25] vs 0.23 [IQR, 0.17-0.25], P = .50) period. By contrast, QTc in V5 and V6 was significantly lower in patients with Kawasaki disease and coronary involvement in the acute period (V5: 378 ms [IQR, 364-395 ms] vs 390 ms [IQR, 371-411 ms], P = .04; V6: 377 ms [IQR, 364-392 ms] vs 390 ms [IQR, 371-410 ms], P = .01). A QTc interval of <385 ms in lead V6 was associated with a 2.5-fold increased risk of coronary involvement (OR, 2.5; 95% CI, 1.2-5.3; P = .02).
Conclusions |
Manually measured QTc interval may be a marker of coronary disease in the acute period of Kawasaki disease.
Le texte complet de cet article est disponible en PDF.Abbreviations : 12-lead ECG, AUC, CRP, ECG, QTc, QTd, Te, Tp
Plan
| The authors declare no conflicts of interest. |
Vol 236
P. 108 - septembre 2021 Retour au numéro
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