Epidemiologic of infective endocarditis (IE) is changing and paediatric population is heterogeneous. We compare clinical characteristics according cardiac status among children.

A retrospective multi centric study was conducted over a decade. Clinical presentation, treatment, outcome, microorganism, underlying congenital heart disease data were recorded.

We identified 64 cases of definite IE between January 2008 to December 2018 median age was 8.0 [0.8–13.2] and 26 were girls, S aureus was the most common pathogen, n=22 (34%), presented in Table 1. CHD represented 45 cases of IE and 38 patients had prior cardiac surgery, they were significantly younger and community acquired IE was more common. New cardiac murmur 11 (24%) vs. 11 (58%), P<0.02, acute ischemic stroke 1 (2%) vs. 4 (21%), P<0.02, and heart failure 11 (22%) vs. 10 (54%), P<0.03 were significantly higher in non-CHD group. Major MDC was met more often in patients without CHD than in patients with CHD (84% versus 46%, P<0.006). There was no difference between IE related to children with or without CHD considering the side of the localisation. Valvular replacement was more frequent in this population [13 (28%) vs. 1 (5%) P<0.05]. Overall morbidity rate was not significantly different but neurologic complications were significantly more prevalent in patients without CHD 7 (15) vs. 11 (58). Children without CHD presented significantly more neurologic impairment 1 (2%) vs. 4 (21%), P<0.05.

CHD patients seem older, require more valve replacement and present community acquired infection when patients without CHD presented more neurological outcome and more hospital acquired infection.