Clinicopathological characteristics and survival outcomes for patients with mucinous colorectal cancer liver metastases undergoing hepatic resection: A systematic review and meta-analysis - 12/08/21
, Paul M. Cromwell b, Emir Hoti a, bAbstract |
Background |
Mucinous adenocarcinoma represents a distinct histological subtype of colorectal cancer. To date there has been limited data available for patients with colorectal cancer liver metastases (CRCLM) derived from mucinous adenocarcinoma. This systematic review and meta-analysis aims to provide data on the clinicopathological and survival outcomes of this cohort.
Methods |
Databases were searched for studies comparing clinicopathological and survival outcomes between patients with mucinous CRCLM and CRCLM from adenocarcinoma not otherwise specified who underwent liver resection. A random-effects model was used for analysis.
Results |
Eight studies describing 9157 patients were included. Mucinous CRCLM were positively associated with colon tumors (OR 1⋅64, P = 0⋅01), T3/T4 tumors (OR 1⋅58, P = 0⋅02), node positive tumors (OR 1⋅55, P = 0⋅005). The review also identified a trend towards worse overall survival in patients with mucinous CRCLM.
Conclusions |
Despite the distinct clinicopathological characteristics and impaired long term outcomes of mucinous CRCLM, resection should remain the gold standard where possible.
Le texte complet de cet article est disponible en PDF.Highlights |
• | Mucinous CRC liver metastases are more likely to come from colon tumors. |
• | Mucinous CRC liver metastases are more likely to come from T3 or T4 tumors. |
• | Mucinous CRC liver metastases are more likely to come from node positive tumors. |
• | Mucinous colorectal liver metastases are associated with worse overall survival. |
• | Resection of the metastases should remain the main stay of treatment where possible. |
Keywords : Colorectal cancer, Mucinous colorectal cancer, Liver metastases, Colorectal cancer liver metastases, Liver resection
Plan
Vol 222 - N° 3
P. 529-535 - septembre 2021 Retour au numéro
Article précédent
- Eastern association for the surgery of trauma – quality, patient safety, and outcomes committee - transitions of care: healthcare handoffs in trauma
- Rachel Appelbaum, Shayn Martin, Glen Tinkoff, Jose L. Pascual, Rajesh R. Gandhi
- Predicting prospective resident entrustment: From evaluation to action
- Xiaodong (Phoenix) Chen, Amalia Cochran, Alan E. Harzman, E. Christopher Ellison
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?