Olfactory and gustatory dysfunctions in COVID-19 outpatients: A prospective cohort study - 05/08/21
, B. Sellem c, 1, R. Palich c, d, D. Bendetowicz a, b, R. Agher c, d, C. Delorme a, R. Tubiana c, d, M.-A. Valantin c, d, S. Seang c, d, L. Schneider c, d, A. Fayçal c, Y. Dudoit c, d, B. Abdi d, e, A. Ndoadoumgue d, L. Assoumou d, C. Katlama c, dfor the
COVIDOM-19 PSL group
Bienvenue sur EM-consulte, la référence des professionnels de santé.
Article gratuit.
Connectez-vous pour en bénéficier!
Highlights |
• | Olfactory and gustatory dysfunctions (OGD) appear early in the course of COVID-19. |
• | The median time to complete recovery from OGD was 20 days. |
• | The 30-day recovery rate of OGD was 67.5%. |
• | Complete smell or taste loss is a significant risk factor for late recovery from OGD. |
• | Patients over 40 years old have a significantly increased risk of late recovery from OGD. |
Abstract |
Objectives |
To describe the characteristics, evolution and risk factors for long-term persistence of olfactory and gustatory dysfunctions (OGD) in COVID-19 outpatients.
Patients and methods |
We conducted a prospective study in SARS-CoV-2 infected outpatients with OGD. Weekly phone interviews were set up starting from COVID-19 onset symptoms and over the course of 60 days, using standardized questionnaires that included a detailed description of general symptoms and OGD. The primary outcome was the proportion of patients with complete recovery of OGD at D30. Rate and time to recovery of OGD, as well as risk factors for late recovery (>30 days), were evaluated using Cox regression models.
Results |
Ninety-eight outpatients were included. The median time to onset of OGD after first COVID-19 symptoms was 2 days (IQR 0–4). The 30-day recovery rate from OGD was 67.5% (95% CI 57.1–75.4) and the estimated median time of OGD recovery was 20 days (95% CI 13–26). Risk factors for late recovery of OGD were a complete loss of smell or taste at diagnosis (HR=0.26, 95% CI 0.12–0.56, P=0.0005) and age over 40 years (HR=0.56, 95% CI 0.36–0.89, P=0.01).
Conclusions |
COVID-19 patients with complete loss of smell or taste and over age 40 are more likely to develop persistent OGD and should rapidly receive sensorial rehabilitation.
Le texte complet de cet article est disponible en PDF.Keywords : Anosmia, Ageusia, SARS-CoV-2, Smell, Taste
Plan
Vol 51 - N° 5
P. 440-444 - août 2021 Retour au numéro
Article précédent
- Outcomes of newborns to mothers with COVID-19
- K. Ghema, M. Lehlimi, H. Toumi, A. Badre, M. Chemsi, A. Habzi, S. Benomar
- Cefepime use: A need for antimicrobial stewardship
- Alexandre Meurant, François Guérin, Simon Le Hello, Guillaume Saint-Lorant, Arnaud de La Blanchardière
Bienvenue sur EM-consulte, la référence des professionnels de santé.