Biomarkers to predict FDG PET/CT activity after the standard duration of treatment for spinal tuberculosis: An exploratory study - 27/07/21
, James Warwick c , Novel N. Chegou d , Johan H. Davis a, b , Caroline G.G. Beltran d , Stephanie Griffith-Richards e , Martin Kidd f , Jacques du Toit a , Robert P. Lamberts a , Gerhard Walzl d Abstract |
Objectives |
18F-Fluorodeoxyglucose (FDG) Positron Emission Tomography- Computed Tomography (PET/CT) scans can be used to assess healing following treatment for spinal tuberculosis (TB) but have limited accessibility and high cost. This study investigated the association between immune biomarkers and FDG-PET/CT activity after ≥9 months of treatment for spinal TB.
Methods |
Patients who had completed ≥9 months of treatment for spinal TB were recruited from a major hospital in the Western Cape, South Africa. Participants underwent a FDG-PET/CT scan and FDG- PET/CT activity was quantified for all spinal and extra-spinal sites. Participants also provided a blood sample, which was evaluated for 19 cytokines along with erythrocyte sedimentation rate (ESR). Correlations and multiple regression analyses were used to investigate the association between biomarkers and PET/CT measures.
Results |
Twenty-eight patients were recruited, of whom 24 (86%) had spinal and/or extra-spinal FDG-PET/CT activity. In the strongest multiple regression model, CXCL10/IP-10, VEGFA, IFN-γ, CRP and Factor D/Adipsin explained 52% of the variation in overall maximal FDG uptake. Conventional monitoring marker ESR showed no significant association with PET/CT measures.
Conclusions |
The current findings offered encouragement that biomarkers to predict FDG-PET/CT activity may show some promise and identified candidate biomarkers for further investigation in this regard.
Le texte complet de cet article est disponible en PDF.Highlights |
• | Most individuals still had FDG-PET/CT activity at the spine lesion after ≥9 months of TB treatment. |
• | Conventional monitoring marker ESR showed no association with FDG-PET/CT activity. |
• | A novel five-biomarker signature explained 52% of maximal FDG-PET/CT activity. |
• | Biomarker/PET/CT associations varied with HIV status and/or previous TB. |
Keywords : Tuberculosis, Spinal, Biomarkers, Positron emission tomography, Treatment response
Plan
Vol 129
Article 102107- juillet 2021 Retour au numéro
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