Delaying definitive resection in early stage (I/II) colon cancer appears safe up to 6 weeks - 26/07/21
, Sean C. Glasgow, Steven R. Hunt, Matthew G. Mutch, Paul E. Wise, Matthew L. Silviera, Radhika K. SmithAbstract |
Background |
The objective of this study was to determine if there is an impact of surgical delay on 5-year overall survival (OS) from early stage colon cancer, and if so, to define how long surgery can safely be postponed.
Methods |
Using the NCDB, we compared early (14–30 days) and delayed surgery (31–90 days) in patients with Stage I/II colon cancer. Outcomes included OS at five years and odds of death.
Results |
Delayed resection conferred a decreased 5-year OS of 73.0% (95% CI, 72.6–73.4), compared to early resection 78.3% (95% CI, 77.9–78.8). When time to surgery was divided into one-week intervals, there was no difference in the odds of death with delay up to 35–41 days (6 weeks), but odds of death increased by 9% per week thereafter.
Conclusions |
These data support that definitive resection for early stage colon cancer may be safely delayed up to 6 weeks.
Le texte complet de cet article est disponible en PDF.Highlights |
• | It is unknown if resection can be safely delayed in patients with early stage colon cancer. |
• | Retrospective analysis of 107,774 stage I/II colon cancer patients divided into early (14–30d) versus delayed (31–90d) cohorts. |
• | Delayed resection conferred a decreased 5-year OS (73.0%) compared to early resection (78.3%). |
• | Odds of death for each additional week of delay did not differ up to 6 weeks, but increased by 9% per week thereafter. |
Keywords : Colon cancer, Cancer outcomes, Surgical delay, Overall survival
Plan
Vol 222 - N° 2
P. 402-407 - août 2021 Retour au numéro
Article précédent
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