Genomic survey of SARS-CoV-2 vaccine breakthrough infections in healthcare workers from Kerala, India - 24/07/21
Doi : 10.1016/j.jinf.2021.05.018
Beena Philomina J a, 1, Bani Jolly b, c, 1, Neethu John d, Rahul C. Bhoyar b, Nisha Majeed e, Vigneshwar Senthivel b, c, Fairoz CP a, Mercy Rophina b, c, Bindhu Vasudevan f, Mohamed Imran b, c, Prasanth Viswanathan g, V.R. Arvinden b, c, Anoop Joseph h, Mohit Kumar Divakar b, c, Priyanka R Nair g, Afra Shamnath b, P. Jayesh Kumar i, Abhinav Jain b, c, P. Geetha i, Anjali Bajaj b, c, Samatha Mathew b, c, Vishu Gupta b, c, Srashti Jyoti Agrawal b, c, Vinod Scaria b, c, ⁎ 
, Sridhar Sivasubbu b, c, ⁎ , Chandni Radhakrishnan j, ⁎
, Sridhar Sivasubbu b, c, ⁎ , Chandni Radhakrishnan j, ⁎ a Department of Microbiology, Government Medical College, Kozhikode, Kerala, India
b CSIR Institute of Genomics and Integrative Biology (CSIR-IGIB), Mathura Road, New Delhi, India
c Academy for Scientific and Innovative Research, Human Resource Development Centre Campus, Ghaziabad, Uttar Pradesh, India
d Department of Microbiology, Government Medical College, Ernakulam, Kerala, India
e Department of Microbiology, Government Medical College, Idukki, Kerala, India
f Department of Community Medicine, Government Medical College, Ernakulam, Kerala, India
g Viral Research and Diagnostic Laboratories, Government Medical College, Kozhikode, Kerala, India
h Department of General Medicine, Government Medical College, Ernakulam, Kerala, India
i Department of General Medicine, Government Medical College, Kozhikode, Kerala, India
j Department of Emergency Medicine, Government Medical College, Kozhikode, Kerala, India
⁎⁎Corresponding authors at: CSIR-Institute of Genomics and Integrative Biology, Sukhdev Vihar, New Delhi 110025, India.Ramachandran Knowledge Center for Genome InformaticsCSIR-Institute of Genomics and Integrative BiologySukhdev ViharNew Delhi110025India⁎Corresponding author at Emergency Medicine, Government Medical College, Kozhikode, Kerala 673008, India.Emergency Medicine, Government Medical CollegeKozhikodeKerala673008India
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Highlights |
• | All 6 patients presented with symptomatic COVID-19 breakthrough infection. |
• | 2 patients were infected despite the presence of SARS-CoV-2 antibodies. |
• | 4 fully vaccinated patients were infected with B.1.1.7 variant of SARS-CoV-2. |
• | Spike variants E484K and S477N were found in SARS-CoV-2 isolates from 2 patients. |
• | None of the patients presented with severe disease or required hospitalization. |
Keywords : COVID-19, SARS-CoV-2, Breakthrough infection, Vaccine, Whole-genome sequencing
© 2021
Publié par Elsevier Masson SAS.
Vol 83 - N° 2
P. 237-279 - août 2021 Retour au numéro
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