Sex Differences in MicroRNA Expression and Cardiometabolic Risk Factors in Hispanic Adolescents with Obesity - 22/07/21
Abstract |
Objective |
To evaluate sex differences in microRNA (miRNA) expression, anthropometric measures, and cardiometabolic risk factors in Hispanic adolescents with obesity.
Study design |
Cross-sectional study of 68 (60% male) Hispanic adolescents with obesity, aged 13-17 years, recruited from a pediatric weight management clinic. We used small RNA sequencing to identify differentially expressed circulating miRNAs. We used ingenuity pathway analysis and David bioinformatic resource tools to identify target genes for these miRNAs and enriched pathways. We used standard procedures to measure anthropometric and cardiometabolic factors.
Results |
We identified 5 miRNAs (miR-24-3p, miR-361-3p, miR-3605-5p, miR-486-5p, and miR-199b-3p) that differed between females and males. miRNA targets-enriched pathways included phosphatidylinositol 3-kinase-protein, 5' AMP-activated protein kinase, insulin resistance, sphingolipid, transforming growth factor-β, adipocyte lipolysis regulation, and oxytocin signaling pathways. In addition, there were sex differences in blood pressure, skeletal muscle mass, lean body mass, and percent body fat.
Conclusions |
We have identified sex differences in miRNA expression in Hispanic adolescents relevant to cardiometabolic health. Future studies should focus on sex-specific mechanistic roles of miRNAs on gene pathways associated with obesity pathophysiology to support development of precision cardiometabolic interventions.
Le texte complet de cet article est disponible en PDF.Abbreviations : BP, miRNA, PI3K-AKT
Plan
Supported by the Texas Biomedical Research Institute Pilot grant (17-04625 [to G.K. and S.C.]), Texas Biomedical Research Institute Healthy Babies Project (to A.B. and L.C.), and the National Institutes of Health (K01 HL130697 [to G.K.]). The authors declare no conflicts of interest. |
Vol 235
P. 138 - août 2021 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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