Impact of obesity and diabetes mellitus in critically ill patients with SARS-CoV-2 - 12/07/21
, Jorge Alberto Castañón-González b, Salvador Ortiz-Gutiérrez a, Jessica Garduño-López b, Yuritzy Luna-Camacho a
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Highlights |
• | The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has spread quickly from Wuhan, China, to a growing number of countries. |
• | Patients with diabetes had increased risk of mortality of 2.86, those patients who, in addition to diabetes had obesity, the risk was 3.17. |
• | Patients with obesity had 1.25 times greater risk of developing a severe SARS-CoV-2 infection. |
• | There is a negative correlation between BMI and the PaO2/FiO2 ratio. |
• | Obese patients required more days of mechanical ventilation and longer hospital stay compared to non-obese patients. |
Abstract |
Purpose |
Evaluate the associations of obesity and diabetes with the risk of mortality in critically ill patients infected with SARS-CoV-2.
Materials and methods |
This cohort study included 115 adult patients admitted to the ICU with SARS-CoV-2 pneumonia. Anthropometric variables and biochemical (C-reactive protein, ferritin, leukocyte, neutrophils, and fibrinogen) were measured. Multivariate logistic regression analyses were used to investigate the associations.
Results |
Mean age was 50.6±11.2 years, 68.7% were male. Median BMI was 30.9kg/m2. All patients had invasive mechanical ventilation. Patients with diabetes had increased risk of mortality with OR of 2.86 (CI 95% 1.1–7.4, p=0.026); among those patients who, in addition to diabetes had obesity, the risk was de 3.17 (CI 95% 1.9–10.2, p=0.038). Patients with obesity had 1.25 times greater risk of developing a severe SARS-CoV-2 infection (95% CI 1.09–1.46, p=0.025). Negative correlation was observed between BMI and the PaO2/FiO2 ratio (r=−0.023, p<0.05). Obese patients required more days of mechanical ventilation and longer hospital stay compared to non-obese patients.
Conclusions |
Diabetes and obesity are risk factors for increasing severity of SARS-CoV-2 infection, and they are both associated with an increase in mortality.
Le texte complet de cet article est disponible en PDF.Keywords : Obesity, Diabetes mellitus, Critical care, SARS-CoV-2, COVID19, Severe acute respiratory syndrome
Plan
Vol 15 - N° 4
P. 402-405 - juillet 2021 Retour au numéro
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