Molecular surveillance of HIV-1 newly diagnosed infections in Shenzhen, China from 2011 to 2018 - 19/06/21
, Jin Zhao b, ⁎ , Lin Li a, ⁎ Highlights |
• | A systematic surveillance on severe HIV-1 epidemic in Shenzhen, China. |
• | CRF07_BC was the most prevalent HIV-1 subtypes during 2011 to 2018 in Shenzhen. |
• | Total TDR was 6.02%. |
• | CRF01_AE, CRF08_BC, CRF55_01B and subtype B were more likely to be associated with TDRAMs than CRF07_BC. |
• | Patients younger than 30 and over 50 years were more likely to cluster. |
Abstract |
Objectives |
Shenzhen is suffering severe HIV epidemic. No systematic surveillance on high risk populations, HIV genetic diversity, transmitted drug resistance (TDR) and molecular transmission clusters (MTCs) have been reported yet. In this study, we described them based on newly diagnosed HIV positive cases from 2011 to 2018 in Shenzhen city, China.
Methods |
Plasma samples of newly reported HIV positive cases in Shenzhen, China were collected from 2011 to 2018. The HIV pol gene was amplified and sequenced for subtyping, genetic characterization, TDR and phylogenetic analysis. Demographic and risk characteristics associated with transmitted drug resistance-associated mutations (TDRAMs) and MTCs were explored by using logistic regression analyses.
Results |
10,378 HIV pol sequences were successfully obtained from newly diagnosed patients with available background information. The most prevalent HIV-1 subtype was CRF07_BC (40.92%). CRF07_BC, CRF55_01B and URFs increased across years. Total TDR was 6.02% during 2011 to 2018. CRF01_AE, CRF08_BC, CRF55_01B and subtype B were more likely to be associated with TDRAMs than CRF07_BC. 4460 (42.98%) patients were infected with strains included in MTCs. Patients younger than 30 and over 50 years were more likely to cluster.
Conclusions |
The prevalence of HIV-1 drug resistance and molecular transmission clusters in Shenzhen should raise a high alert. Interventions targeting on patients with strains locating in MTCs should be considered to improve prevention effect in Shenzhen.
Le texte complet de cet article est disponible en PDF.Keywords : HIV, High risk population, Subtypes, Transmitted HIV drug resistance, Molecular transmission clusters
Abbreviations : DRMs, IQR, MSM, MTCs, NNRTI, NRTI, PI, TDR, TDRAMs, URFs
Plan
Vol 83 - N° 1
P. 76-83 - juillet 2021 Retour au numéro
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