Prospective observational trial of low-dose skin electron beam therapy in mycosis fungoides using a rotational technique - 07/06/21
, Chirayu G. Patel, MD, MPH b, George X. Ding, PhD a, John A. Zic, MD c, Jeffrey Zwerner, MD, PhD c, Evan C. Osmundson, MD, PhD a, Austin N. Kirschner, MD, PhD aAbstract |
Introduction |
Low-dose total skin electron beam therapy provides a durable treatment response for skin lesions caused by cutaneous T-cell lymphoma. We prospectively assessed the durability of response and quality of life for patients receiving low-dose total skin electron beam therapy using a novel rotational technique and dosing regimen.
Methods |
Patients completed baseline Skindex-29 quality-of-life surveys and had baseline Modified Severity-Weighted Assessment Tool score recorded. Patients received 12 Gy in 12 fractions with a dual-field rotational technique. The primary outcome was overall response rate, with the secondary outcomes being time to treatment response, duration of clinical benefit, and quality-of-life change.
Results |
We enrolled 20 patients and recorded an overall response rate of 90%. The median time to treatment response was 6.5 weeks. The baseline Modified Severity-Weighted Assessment Tool score was 55.6 and it declined to a median of 2.2 at last follow-up (P < .001). The median duration of clinical benefit was 21 months. There was a decline in the Skindex-29 total score and every subdomain when each follow-up visit was compared (P = .004).
Conclusions |
This prospective study demonstrated a very high overall response rate and improvement in skin-related quality of life. Low-dose rotational total skin electron beam therapy can be implemented routinely in clinical practice.
Le texte complet de cet article est disponible en PDF.Abbreviations used : CR, IQR, OSLD, TSEBT
Plan
| Funding sources: Supported by National Institutes of Health grant 5K12CA090625-18 to Dr Kirschner from the Vanderbilt Clinical Oncology Research Career Development Program. |
|
| IRB approval status: Approval number: 151608. |
|
| Reprints not available from the authors. |
Vol 85 - N° 1
P. 121-127 - juillet 2021 Retour au numéro
Article précédent
- Morphea patients with mucocutaneous involvement: A cross-sectional study from the Morphea in Adults and Children (MAC) cohort
- Smriti Prasad, Samantha M. Black, Jane L. Zhu, Shivani Sharma, Heidi Jacobe
- Impact of the time interval between primary melanoma excision and sentinel node biopsy: A systematic review and meta-analysis
- Pablo Vargas-Mora, Leonardo Peruilh-Bagolini, Rubén González-Cuevas, Pedro Ferrer-Rosende
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?