Morphea patients with mucocutaneous involvement: A cross-sectional study from the Morphea in Adults and Children (MAC) cohort - 07/06/21
Abstract |
Background |
Demographic and clinical findings of patients with mucocutaneous morphea have not been well characterized, to our knowledge.
Objective |
To determine the demographic and clinical characteristics of morphea patients with mucocutaneous lesions who were enrolled in the Morphea in Adults and Children cohort.
Methods |
Cross-sectional study of 735 patients in the Morphea in Adults and Children cohort from 2007 to 2018.
Results |
A total of 4.6% of linear morphea patients had oral involvement versus 2.4% among the entire cohort, whereas 10.3% of generalized morphea patients had genital involvement versus 3.7% among the entire cohort. Patients with genital lesions were older at disease onset than those with oral morphea (57 versus 11.5 years; P < .001) and had more frequent extragenital lichen sclerosus et atrophicus (59.2% versus 5.6%; P = .004).
Limitations |
Selection bias and limited number of affected subjects.
Conclusion |
Oral morphea lesions predominate in younger patients with facial linear morphea, whereas genital lesions predominate in postmenopausal women with overlying extragenital lichen sclerosus et atrophicus.
Le texte complet de cet article est disponible en PDF.Key words : lichen sclerosus atrophicus, localized scleroderma, Localized Scleroderma Activity Index, Localized Scleroderma Damage Index, morphea, mucocutaneous morphea, Physician Global Assessment of Disease Activity, Physician Global Assessment of Disease Damage
Abbreviations used : IQR, LSA
Plan
| Funding sources: Supported in part by National Institutes of Health/National Institute of Arthritis and Musculoskeletal and Skin Disease grant R01AR073516 and the James N. Gilliam, MD Chair in Dermatology. |
|
| IRB approval status: Reviewed and approved by the institutional review board at the University of Texas Southwestern (UTSW) protocol STU112010-028. |
|
| Reprints not available from the authors. |
Vol 85 - N° 1
P. 114-120 - juillet 2021 Retour au numéro
Article précédent
- Clinical characteristics and histopathologic changes of morphea: A single-center, retrospective study of 137 patients
- Jemin Kim, Kyung Bae Chung, Young In Lee, Jihee Kim, Ju Hee Lee
- Prospective observational trial of low-dose skin electron beam therapy in mycosis fungoides using a rotational technique
- Neil B. Newman, Chirayu G. Patel, George X. Ding, John A. Zic, Jeffrey Zwerner, Evan C. Osmundson, Austin N. Kirschner
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?