Diaphragm ultrasound in the diagnosis of respiratory dysfunction in patients with amyotrophic lateral sclerosis - 29/05/21
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| pages | 8 |
| Iconographies | 4 |
| Vidéos | 0 |
| Autres | 0 |
Highlights |
• | Diaphragm ultrasonography (DUS) can provide functional and structural information of diaphragm. |
• | Diaphragm thicknesses assessed by sonography have significant correlations with pulmonary function tests in ALS. |
• | ΔTmax is the most valuable DUS index in the diagnosis of diaphragmatic dysfunction. |
Abstract |
Objective |
In this study, we aimed to select the best diaphragm ultrasonography (DUS) parameter as an alternative index for the diagnosis of lung function impairment in amyotrophic lateral sclerosis (ALS).
Methods |
Twenty-nine patients with ALS and 15 healthy subjects were enrolled in the study. DUS, lung function tests, phrenic nerve conduction study and arterial blood gas analysis were performed.
Results |
Patients with respiratory dysfunction had a significantly lower level of ΔTmax than those without (P=0.039). Significant correlations (P<0.05) were found between forced vital capacity (FVC) and Tdi-ins (r=0.665, P<0.0001) and ΔTmax (r=−0.748, P<0.0001) and Δins-exp (r=0.627, P<0.0001) and ΔTdi (r=0.485, P<0.0001). Receiver Operating Curves analysis demonstrated that ΔTmax (AUC=0.76, P=0.044) had a better overall accuracy for detection of respiratory dysfunction compared with Tdi-ins (AUC=0.27, P=0.067), Δins-exp (AUC=0.312, P=0.139), and ΔTdi (AUC=0.38, P=0.359).
Conclusion |
ΔTmax is the most valuable DUS index in the diagnosis of diaphragmatic dysfunction.
Significance |
DUS can provide functional and structural information of diaphragm and help to diagnose diaphragmatic dysfunction in ALS.
Le texte complet de cet article est disponible en PDF.Keywords : Amyotrophic lateral sclerosis, Diaphragmatic ultrasonography, Pulmonary function tests, Phrenic nerve conduction
Plan
Vol 177 - N° 6
P. 639-646 - juin 2021 Retour au numéro
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