The dynamics of procalcitonin in COVID-19 patients admitted to Intensive care unit - a multi-centre cohort study in the South West of England, UK. - 12/05/21
Doi : 10.1016/j.jinf.2021.03.011
Philip Williams a, e, ⁎ 
, Chris McWilliams a, b, Kamran Soomro b, c, Irasha Harding e, Stefan Gurney b, Matt Thomas d, Maha Albur d, O. Martin Williams e
, Chris McWilliams a, b, Kamran Soomro b, c, Irasha Harding e, Stefan Gurney b, Matt Thomas d, Maha Albur d, O. Martin Williams e a University of Bristol UK
b University Hospitals Bristol and Weston NHS Trust UK
c University of the West of England UK
d North Bristol NHS Trust UK
e PHE National Infection Service UK
⁎Corresponding author.
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Highlights |
• | We have undertaken a retrospective observational study describing the dynamics of PCT and CRP, including the response to antibiotic treatment, in adults with severe COVID-19 infection requiring ICU admission. |
• | Results were compared to two better-understood groups of patients from historical data, adult ICU patients with either bacteraemia or influenza. |
• | Elevated PCT in the first 48 h of admission was rare in COVID-19 patients. Where PCT was recorded it was <1.0 ng/L in 68.9% of COVID compared to 38% influenza patients. |
• | PCT was low throughout the study, or responded rapidly to antibiotics 65.4% and 82.6% of COVID-19 and influenza patients respectively. |
• | The dynamics of PCT in COVID-19 patients are consistent with a response to secondary bacterial infection and are not consistent with an inflammatory response to COVID-19 alone, and in contrast to CRP, PCT appears to be a useful biomarker in identifying COVID-19 patients with super-added bacterial. |
| PW was partially funded by MRC grant MR/T005408/1. |
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| CM was partially funded by HDR UK South West Better Care Partnership. |
© 2021
Publié par Elsevier Masson SAS.
Vol 82 - N° 6
P. e24-e26 - juin 2021 Retour au numéro
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