Do not neglect SARS-CoV-2 hospitalization and fatality risks in the middle-aged adult population - 08/05/21

Doi : 10.1016/j.idnow.2020.12.007

Nathanael Lapidus ^a,^{^{1
The first authors contributed equally to this article.},}^⁎ , Juliette Paireau ^b,^c,^{^{1
The first authors contributed equally to this article.}}, Daniel Levy-Bruhl ^c, Xavier de Lamballerie ^d, Gianluca Severi ^e,^f, Mathilde Touvier ^g, Marie Zins ^h,ⁱ, Simon Cauchemez ^b,^{^{2
The senior authors contributed equally to this article.}}, Fabrice Carrat ^a,^{^{2
The senior authors contributed equally to this article.}}
for the SAPRIS-SERO study group^³
Members of the SAPRIS-SERéO study group are listed in the Supplementary Materials section.
^a Sorbonne Université, Inserm, Institut Pierre-Louis d’Epidémiologie et de Santé Publique, Département de Santé Publique, Hôpital Saint-Antoine, APHP, Paris, France
^b Mathematical Modelling of Infectious Diseases Unit, Institut Pasteur, UMR2000, CNRS, Paris, France
^c Santé Publique France, French National Public Health Agency, Saint-Maurice, France
^d Unité des Virus Emergents, UVE: Aix Marseille Univ, IRD 190, Inserm 1207, IHU Méditerranée Infection, 13005 Marseille, France
^e Department of Statistics, Computer Science and Applications, University of Florence, Italy
^f CESP UMR1018, Université Paris-Saclay, UVSQ, Inserm, Gustave Roussy, Villejuif, France
^g Sorbonne Paris Nord University, Inserm U1153, Inrae U1125, Cnam, Nutritional Epidemiology Research Team (EREN), Epidemiology and Statistics Research Center–University of Paris (CRESS), Bobigny, France
^h Paris University, Paris, France
ⁱ Paris Saclay University, Inserm UMS 11, Villejuif, France

^⁎Corresponding author at: Institut Pierre Louis d’Épidémiologie et de Santé Publique, 27, rue Chaligny, 75571 Paris cedex 12, France.Institut Pierre Louis d’Épidémiologie et de Santé Publique27, rue ChalignyParis cedex 1275571France

connectez-vous ou créez un compte

Bienvenue sur EM-consulte, la référence des professionnels de santé.
Article gratuit.

Connectez-vous pour en bénéficier!

Highlights

•	During the first wave of the pandemic in France, the estimated overall infection hospitalization ratio (IHR, probability of hospitalization in infected adults) was 2.7%.
•	At that time, the estimated overall infection fatality ratio (IFR, probability of death in infected adults) was 0.49%.
•	Both IHR and IFR were higher in men.
•	IHR approximately doubled every 10 years while IFR doubled every 5 years.
•	IFR should not be neglected, even in young and middle-aged adults (0.042% in individuals aged 40-50 years).

Le texte complet de cet article est disponible en PDF.

Abstract

Objectives

This study aimed at estimating the SARS-CoV-2 infection hospitalization (IHR) and infection fatality ratios (IFR) in France.

Patients and methods

A serosurvey was conducted in 9782 subjects from the two French regions with the highest incidence of COVID-19 during the first wave of the pandemic and coupled with surveillance data.

Results

IHR and IFR were 2.7% and 0.49% overall. Both were higher in men and increased exponentially with age. The relative risks of hospitalization and death were 2.1 (95% CI: 1.9-2.3) and 3.8 (2.4-4.2) per 10-year increase, meaning that IHR and IFR approximately doubled every 10 and 5 years, respectively. They were dramatically high in the very elderly (80-90 years: IHR: 26%, IFR: 9.2%), and also substantial in younger adults (40-50 years: IHR: 0.98%, IFR: 0.042%).

Conclusions

These findings support the need for comprehensive preventive measures to help reduce the spread of the virus, even in young or middle-aged adults.

Le texte complet de cet article est disponible en PDF.

Keywords : Adult, Age-Specific Death Rate, COVID-19, France, SARS-CoV-2

Plan

Introduction

Materials and methods

Authors’ contributions

Disclosure of interest

Export

Vol 51 - N° 4

P. 380-382 - juin 2021 Retour au numéro

Article précédent

Does a 5-day course of antibiotics in elderly patients with community-acquired pneumonia achieve the established criteria of clinical stability?
C. Flateau, M. Dinia, N. Raulet, S. Sayegh, S. Diamantis, M. Jager

| Article suivant

Invasive Aspergillosis associated with Covid-19: A word of caution
Laura Gouzien, Theophile Cocherie, Odile Eloy, Stéphane Legriel, Jean-Pierre Bedos, Christelle Simon, Stephanie Marque-Juillet, Alexis Ferré, Fabrice Bruneel

Bienvenue sur EM-consulte, la référence des professionnels de santé.

connectez-vous ou créez un compte

Do not neglect SARS-CoV-2 hospitalization and fatality risks in the middle-aged adult population - 08/05/21

Highlights

Abstract

Objectives

Patients and methods

Results

Conclusions

Plan

Export citations

Fichier

Contenu

Accès rapides

Mon compte

Aide & support

Plateformes Elsevier Masson

Déclaration CNIL