Early clinical experience with imatinib in COVID-19: Searching for a dual effect - 25/04/21
Doi : 10.1016/j.jinf.2021.02.002
Alejandro Morales-Ortega a, ⁎ 
, Luis Rivas-Prado a, Begoña Frutos-Pérez a, Beatriz Jaenes-Barrios b, Ana Isabel Farfán-Sedano a, Carlos Javier García-Parra c, Belén Hernández-Muniesa d, Miguel Ángel Duarte-Millán a, Elena Madroñal-Cerezo a, Ana Ontañón-Nasarre d, José Manuel Ruiz-Giardín a, Fernando Bermejo e, Mario García-Gil d, Sonia Gonzalo-Pascua a, Juan Víctor San Martín-López a, David Bernal-Bello a
, Luis Rivas-Prado a, Begoña Frutos-Pérez a, Beatriz Jaenes-Barrios b, Ana Isabel Farfán-Sedano a, Carlos Javier García-Parra c, Belén Hernández-Muniesa d, Miguel Ángel Duarte-Millán a, Elena Madroñal-Cerezo a, Ana Ontañón-Nasarre d, José Manuel Ruiz-Giardín a, Fernando Bermejo e, Mario García-Gil d, Sonia Gonzalo-Pascua a, Juan Víctor San Martín-López a, David Bernal-Bello a a Department of Internal Medicine, Hospital Universitario de Fuenlabrada, Madrid, Spain
b Primary Health Care Center Castilla La Nueva, Fuenlabrada, Madrid, Spain
c Department of Emergency Medicine, Hospital Universitario de Fuenlabrada, Madrid, Spain
d Department of Hospital Pharmacy, Hospital Universitario de Fuenlabrada, Madrid, Spain
e Department of Gastroenterology, Hospital Universitario de Fuenlabrada. Instituto de Investigación, Sanitaria Hospital La Paz (IdiPAZ), Madrid, Spain
⁎Corresponding author.
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Highlights |
• | Imatinib has shown antiviral and immunomodulatory properties in preclinical models. |
• | Imatinib could potentially be helpful in COVID-19. |
• | This is the first case series of COVID-19 patients treated with imatinib. |
• | Imatinib is a well-known drug whose safety profile seems acceptable in COVID-19. |
Graphical abstract |
Plan
© 2021
Publié par Elsevier Masson SAS.
Vol 82 - N° 5
P. 186-230 - mai 2021 Retour au numéro
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