The Infant Microbiome and Its Impact on Development of Food Allergy - 14/04/21

Doi : 10.1016/j.iac.2021.01.004

Kylie N. Jungles, MD ^a,^b,^{^{1
Have contributed equally.}}, Kassidy M. Jungles, BS ^c,^{^{1
Have contributed equally.}}, Leah Greenfield, BS ^b,^d, Mahboobeh Mahdavinia, MD, PhD ^b,^⁎,^{^{1
Have contributed equally.}}
^a Department of Pediatrics, University of Michigan C.S. Mott Children’s Hospital, 1540 E Hospital Dr #4204, Ann Arbor, MI 48109, USA
^b Department of Internal Medicine, Allergy and Immunology Division, Rush University Medical Center, 1725 West Harrison Street, Suite 117, Chicago, IL 60612, USA
^c Department of Pharmacology, University of Michigan, 1150 W Medical Center Dr, Ann Arbor, MI 48109, USA
^d Rush Medical College, 600 S Paulina St Suite 524, Chicago, IL 60612, USA

^∗Corresponding author. Allergy and Immunology Division, Internal Medicine Department, Rush University Medical Center, 1725 West Harrison Street, Suite 117, Chicago, IL 60612.Allergy and Immunology DivisionInternal Medicine DepartmentRush University Medical Center1725 West Harrison StreetSuite 117ChicagoIL60612

Résumé

The prevalence of food allergy (FA) has been increasing over the past few decades; recent statistics suggest that FA has an impact on up to 10% of the population and 8% of children. Although the pathogenesis of FA is unclear, studies suggest gut microbiome plays a role in the development of FA. The gut microbiome is influenced by infant feeding method, infant diet, and maternal diet during lactation. Breastfeeding, Mediterranean diet, and probiotics are associated with commensal gut microbiota that protect against FA. This area of research is essential to discovering potential preventive methods or therapeutic targets against FA.

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Keywords : Food allergy (FA), Gut microbiome, Mediterranean diet, Prevotella copri (P copri)