Elevated neutrophil to lymphocyte ratio is associated with poor long-term survival and graft failure after lung transplantation - 12/04/21
Abstract |
Purpose |
We aimed to assess the prognostic value of Neutrophil to Lymphocyte Ratio (NLR) on long-term outcomes and graft dysfunction after lung transplantation.
Methods |
We retrospectively reviewed all patients receiving a lung transplant at our institution from 2011 to 2014. The primary exposure was elevated NLR at the time of transplant, defined by NLR>4. The primary outcomes were graft failure and three-year all-cause mortality. Multivariate logistic regression and Kaplan-Meier survival analysis were used to analyze outcomes.
Results |
95 patients were included. 40 patients (42%) had an elevated NLR. Elevated NLR was associated with graft failure (OR: 4.7 [1.2–18.8], p = 0.02), and three-year mortality (OR: 5.4 [1.3–23.2], p = 0.03) on multivariate logistic regression. Patients with elevated NLR demonstrated significantly lower survival on Kaplan-Meier analysis (50% versus 74%, p = 0.02). The c-statistic for our multivariate model was 0.91.
Conclusion |
Elevated neutrophil to lymphocyte ratio is associated with poor long-term survival and graft failure after lung transplantation.
Le texte complet de cet article est disponible en PDF.Key Points |
• | A neutrophil to lymphocyte ratio (NLR) greater than 4 is considered elevated. |
• | Elevated NLR is associated with lower long-term survival after lung transplant. |
• | Elevated NLR is associated with graft failure after lung transplantation. |
• | Elevated NLR is not associated with lower short-term survival after lung transplant. |
Keywords : Transplantation, Lung transplantation, Immunology, Biomarker, Outcomes
Plan
Vol 221 - N° 4
P. 731-736 - avril 2021 Retour au numéro
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