Association of Cesarean Delivery with Childhood Hospitalization for Infections Before 13 Years of Age - 22/03/21
, Safiya Soullane, MDc 4, Thuy Mai Luu, MD, MSc, FRCPC 6, 8, Ga Eun Lee, MScPH 1, 2, Shu Qin Wei, MD, PhD 2, 8, Caroline Quach, MD, MSc, FRCPC 7, 8Abstract |
Objectives |
To determine the association between cesarean delivery and childhood infections up to 13 years of age.
Study design |
We conducted a longitudinal cohort study of 731 803 children born between 2006 and 2016 at all hospitals in the province of Quebec, Canada. We followed children born by cesarean, operative vaginal, and nonoperative vaginal delivery up to 13 years of age. Outcomes included hospitalization for otitis media, respiratory, infectious enteritis, and other infections. We estimated hazard ratios with 95% CIs for the association between mode of delivery and childhood infections, adjusted for patient characteristics.
Results |
At age 3-4 years, cesarean delivery was associated with a 1.07-fold greater risk of otitis media (95% CI, 1.03-1.11), a 1.15-fold greater risk of respiratory infection (95% CI, 1.09-1.22), and a 1.13-fold greater risk of infectious enteritis (95% CI, 1.03-1.25) compared with nonoperative vaginal delivery. However, operative vaginal delivery was associated with these same outcomes. Both cesarean and operative vaginal delivery were more strongly associated with infection hospitalization before age 1 year, but associations disappeared after 5 years.
Conclusions |
Cesarean delivery is associated with infection hospitalization before but not after age 5 years. However, associations were also present for operative vaginal delivery, which suggests that mechanisms other than exposure to maternal vaginal flora explain the relationship.
Le texte complet de cet article est disponible en PDF.Keywords : communicable diseases, delivery, obstetric, microbiota, obstetrical forceps, vacuum extraction
Plan
| Funded by the Canadian Institutes of Health Research (PJT-162300, to N.A.) and the Fonds de recherche du Québec-Santé (34695, to N.A.). The study sponsors were not involved in the study design; the collection, analysis, and interpretation of data; the writing of the report; or the decision to submit the manuscript for publication. The authors declare no conflicts of interest. |
Vol 231
P. 178 - avril 2021 Retour au numéro
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