Emergence of a non vaccine-cognate enterovirus A71 genotype C1 in mainland China - 18/03/21
Highlights |
• | EV-A71 subgenotype C1 was first isolated in China. |
• | C1-GD2019 shared high identity with the C1-like lineage recently identified in Europe and was introduced in 2018–2019. |
• | C1-GD2019 was a recombinant strain originating from C1-like and CVA. |
• | Antigenic variance was found between C1-GD2019 and the circulating C4a strains. |
Summary |
Background |
EV-A71 is a common causative agent of hand foot and mouth disease. In mainland China, EV-A71 subgenotype C4 has been the sole circulating genotype since 2008, and was used in the production of multiple licensed vaccines. Here, we report the first detection EV-A71 C1 strains in China.
Methods |
Full genomic sequence were obtained. The origin of the EV-A71 C1 strains were tracked down by Bayesian inferences. Recombination was analyzed using Simplot program. And the antigenicity were tested using the microneutralization test.
Results |
The C1-GD2019 shared high identity with the C1-like lineage recently identified in Europe and was introduced into Guangdong in 2018–2019. Close genetic relatedness between the C1-GD2019 and Europe C1-like strains were observed except for the 3D-3′UTR region. The late showed high similarity with CVA genomes. Antigenic variance was found. The C1-GD2019 could not be effectively neutralized by EV-A71 C4a neutralizing antibody positive samples.
Conclusion |
This is the first report of EV-A71 subgenotype C1 isolated in China. It is a recombinant strain originating from C1-like strains recently identified in Europe and CVA strains. The different antigenicity between the C1 strains and C4a vaccine strains highlighted the importance on closely monitoring the EV-A71 C1 strains in China.
Le texte complet de cet article est disponible en PDF.Keywords : Enterovirus A71, Genotype C1, Recombination, Antigenicity variance
Plan
Vol 82 - N° 3
P. 407-413 - mars 2021 Retour au numéro
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