Panbio™ rapid antigen test for SARS-CoV-2 has acceptable accuracy in symptomatic patients in primary health care - 18/03/21
, Patricia Lorente a, c , Alfonso Leiva a, b, 1, ⁎ , Eugenia Carandell b, d , Antonio Oliver b, e , Estrella Rojo b, e , Pau Pericas a , Joan Llobera a, b on behalf of
COVID-19 Primary Care Research Group
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Highligths |
• | Most of patients with mild symptoms (up to 75%) and close contacts are visited and followed-up in primary health care centers or test sites. |
• | The present study is the largest evaluation of the Panbio Ag-RDT in samples from symptomatic and asymptomatic patients in real-world context. |
• | We found an overall sensitivity of the Panbio™ rapid antigen test of 71.4% (95% CI: 63.1%, 78.7% and a specificity of 99.8% (95% CI: 99.4%, 99.9%) |
• | Our results support the use of the Ag-RDT for symptomatic patients within 5 days since the onset of the symptoms in PHC setting and test sites. |
Summary |
Objectives |
We aimed to evaluate the accuracy of the Panbio™ Ag-RDT at primary health care (PHC) centers and test sites in symptomatic patients and close contacts, using the Reverse-Transcription Polymerase Chain Reaction (RT-PCR) test as the gold standard.
Methods |
The study was conducted in four PHC centers and two test sites in Mallorca, Spain. Consecutive patients older than 18 years, attending the sites for RT-PCR testing were included. Two nasopharyngeal samples were collected, one for RT-PCR and the other was processed on-site using the Panbio™ rapid antigen test kit for SARS-CoV-2. The sensitivity and specificity were calculated using RT-PCR as the reference, and the predictive values using the pretest probability results for each analyzed group.
Findings |
A total of 1369 participants were included; mean age 42.5 ± 14.9 years and 54.3% women. The overall prevalence was 10.2%. Most participants (70.6%) presented within 5 days of the onset of symptoms. The overall sensitivity was of 71.4% (95% CI: 63.1%, 78.7%), the specificity of 99.8% (95% CI: 99.4%, 99.9%), the positive predictive value of 98.0% (95% CI: 93.0%, 99.7%) and a negative predictive value of 96.8% (95% CI: 95.7%, 97.7%). The sensitivity was higher in symptomatic patients, in those arriving within 5 days since symptom onset and in those with high viral load.
Interpretation |
Ag-RDT had relatively good performance characteristics in suspected symptomatic patients within five days since the onset of symptoms. However, our data do not support the sole use of Panbio™ Ag-RDT in asymptomatic individuals.
Funding |
None
Le texte complet de cet article est disponible en PDF.Keywords : COVID-19, Rapid antigen test, Sar-CoV-2, Primary care
Plan
| COVID-19 Primary Care Research Group members (alphabetical order) Layla Aoukhiyad – pharmacist, Servei de Salut de les Illes Balears; email: layla.aoukhiyad@ibsalut.es Ricardo Arcay – medical microbiologist resident, Son Espases University Hospital Microbiology Unit; email: ricardo.arcay@ssib.es Javier Arranz – general practitioner, Escola Graduada Primary Care Health Center; email: jarranz@ibsalut.caib.es Irene Barrionuevo – nurse, Son Espases University Hospital Emergency Unit; email: irenem.barrionuevo@ssib.es Bernardino Comas – general practitioner, Son Espases University Hospital Emergency Unit; email: bernardino.comas@ssib.es Sara Contreras – biologist, Primary Health Care Research Unit; email: scontreras3@ibsalut.caib.es María Fernandez-Billon – medical microbiologist resident, Son Espases University Hospital Microbiology Unit; email: maria.fernandez-billon@ssib.es J. Luis Ferrer – nurse, Santa Ponça Primary Health Care Center; email: jlferrer@ibsalut.caib.es Pablo Fraile – medical microbiologist resident, Son Espases University Hospital Microbiology Unit; email: pablo.fraile@ssib.es Marina García – general practitioner, Inca Primary Care Health Center; email: marinagarcia@ibsalut.caib.es Carla Iglesias – medical microbiologist resident, Son Espases University Hospital Microbiology Unit; email: carla.iglesias@ssib.es Miquel Llobera – nurse, Santa Ponça Primary Health Care Center; email: mllobera@ibsalut.caib.es M. Consolación Méndez – director of nursing, Mallorca Primary Health Care Directorate; email: mmendez@ibsalut.caib.es Susana Munuera – general practitioner, Servei de Salut de les Isles Balears; email: susana.munuera@ibsalut.es Victoria Pascual – nurse, COVID Express Testing Center; email: avpascual@ibsalut.caib.es Carlos Raduan – general practitioner medical director, Mallorca Primary Health Care Directorate; email: craduan@ibsalut.caib.es Ana Requena – nurse, Coll d'en Rabassa Primary Care Health Center; email: arequena2@ibsalut.caib.es Antonia Roca – general practitioner medical director, Mallorca Primary Health Care Directorate; email: aroca@ibsalut.caib.es Pedro Rull – general practitioner, Son Espases University Hospital Emergency Unit; email: pere.rull@ssib.es Silvia Vallcaneras – nurse, Alcudia Primary Care Health Center; email: svallcaneras@ibsalut.caib.es Verónica Vega – nurse, COVID Express Testing Center. email: vvega@ibsalut.caib.es |
Vol 82 - N° 3
P. 391-398 - mars 2021 Retour au numéro
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