Post-acute COVID-19 syndrome. Incidence and risk factors: A Mediterranean cohort study - 18/03/21
, Esperanza Merino c, 1, ⁎ , Jose-Manuel Leon-Ramirez d, Mariano Andres b, e, Jose Manuel Ramos b, f , Juan Arenas-Jiménez g, Santos Asensio d , Rosa Sanchez h , Paloma Ruiz-Torregrosa d, Irene Galan d, Alexander Scholz f, Antonio Amo f, Pilar González-delaAleja f, Vicente Boix b, c , Joan Gil dOn behalf of
COVID19-ALC research group
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Highlights |
• | Post-COVID syndrome requires, besides symptoms, comprehensive organ damage assessment. |
• | Post-covid syndrome is not limited to severe acute COVID19 patients. |
• | Symptoms are mostly mild, improve with time, and with no identified predictors. |
• | Radiological and spirometric changes are mild and observed in 25% of patients. |
• | Our findings contribute to efficiently designing follow-up plans for COVID patients. |
Summary |
Objectives |
This study aims to analyze the incidence of Post-acute COVID-19 syndrome (PCS) and its components, and to evaluate the acute infection phase associated risk factors.
Methods |
A prospective cohort study of adult patients who had recovered from COVID-19 (27th February to 29th April 2020) confirmed by PCR or subsequent seroconversion, with a systematic assessment 10–14 weeks after disease onset. PCS was defined as the persistence of at least one clinically relevant symptom, or abnormalities in spirometry or chest radiology. Outcome predictors were analyzed by multiple logistic regression (OR; 95%CI).
Results |
Two hundred seventy seven patients recovered from mild (34.3%) or severe (65.7%) forms of SARS-CoV-2 infection were evaluated 77 days (IQR 72–85) after disease onset. PCS was detected in 141 patients (50.9%; 95%CI 45.0–56.7%). Symptoms were mostly mild. Alterations in spirometry were noted in 25/269 (9.3%), while in radiographs in 51/277 (18.9%). No baseline clinical features behaved as independent predictors of PCS development.
Conclusions |
A Post-acute COVID-19 syndrome was detected in a half of COVID19 survivors. Radiological and spirometric changes were mild and observed in less than 25% of patients. No baseline clinical features behaved as independent predictors of Post-acute COVID-19 syndrome development.
Le texte complet de cet article est disponible en PDF.Graphical abstract |
Keywords : COVID-19, Sequelae, Syndrome, Spirometry, Associated factors, Life quality, Health-related quality of life, Diagnostic imaging, Cohort study, Symptoms
Plan
Vol 82 - N° 3
P. 378-383 - mars 2021 Retour au numéro
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