Altered fMRI-derived functional connectivity in patients with high-tension glaucoma - 16/03/21
, Yi Wang e, ⁎ , Weizhao Lu a, d, ⁎ Bienvenue sur EM-consulte, la référence des professionnels de santé.
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Graphical abstract |
Highlights |
• | Functional connectivity was used to assess changes in high-tension glaucoma. |
• | Decreased connection was found between the visual cortex and other regions. |
• | The results revealed new targets for accurate treatment of glaucoma. |
Abstract |
Background |
High-tension glaucoma (HTG) is associated with functional changes in the brain, and elevated intraocular pressure (IOP) is one of the major causes.
Purpose |
To evaluate the effects of high IOP on the brain in patients with HTG by using resting-state functional magnetic resonance imaging (rs-fMRI).
Materials and methods |
Thirty-six patients with HTG and 20 age- and gender-matched healthy controls (HCs) were recruited and underwent IOP examination and rs-fMRI scan. Voxel-wise functional connectivity (FC) values were obtained between the Brodmann Area (BA) 17 (primary visual cortex) and the rest of the brain, two-sample t test was performed between HTG group and HCs. Correlation analysis was performed between FC and clinical information.
Results |
Compared with HCs, HTG patients demonstrated decreased FC between BA 17 and the right precuneus gyrus, decreased FC between BA 17 and the right superior frontal gyrus (SFG) (GRF corrected at voxel level P<0.001 and cluster level P<0.05, two-tailed). FC between BA 17 and the right SFG showed significantly negative correlation with right eyes’ IOP and mean IOP.
Conclusion |
HTG patients had abnormal FC changes between the visual cortex and multiple functional brain regions related to visual sense, memory consolidation and cognitive processing, which provided image support for the pathophysiology research of HTG, and revealed new targets for the accurate treatment of HTG.
Le texte complet de cet article est disponible en PDF.Keywords : High-tension glaucoma, Resting-state functional magnetic resonance imaging, Functional connectivity
Plan
Vol 48 - N° 2
P. 94-98 - mars 2021 Retour au numéro
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