Effects of glutathione S-transferase M1 and T1 deletions on Parkinson's disease risk among a North African population - 09/03/21
, C. Chbili a, S. Ben Amor c, A. Hassine c, S. Ben Ammou c, S. Saguem aBienvenue sur EM-consulte, la référence des professionnels de santé.
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Abstract |
Purpose |
In this study, the effects of glutathione S-transferase polymorphisms Mu1 (GSTM1) and glutathione S-transferase polymorphisms Theta1 (GSTT1) on Parkinson's disease (PD) risk factor were evaluated in a Tunisian population.
Methods |
These polymorphisms were analyzed in 229 healthy Tunisian subjects and 64 Tunisian patients with PD, using a polymerase chain reaction (PCR). Statistical analysis was performed using SPSS 18.0. The relative associations between the GST genotypes and PD were assessed by calculating the odds ratios (ORs) and 95% confidence intervals (CIs).
Results |
The study results demonstrated that the individuals with GSTM1 [OR=3.93, 95% CI: 1.98–7.92, P=10−6] and GSTT1 [OR=5.45, 95% CI: 2.90–10.30, p=10−6] were statistically associated with the risk of PD. A significant association was also found between the individuals with both GSTM1/T1 null genotypes and PD risk [OR=22.10, 95% CI: 6.99–73.75, P=10−6].
Conclusion |
These genotyping findings suggest that the absence of both GSTM1 and GSTT1 activity could be a contributory factor for the development of PD.
Le texte complet de cet article est disponible en PDF.Keywords : Genetic polymorphisms, Glutathione S-transferase M1, Glutathione S-transferase T1, Parkinson's disease
Plan
Vol 177 - N° 3
P. 290-295 - mars 2021 Retour au numéro
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