Epilepsy and pregnancy: What should the neurologists do? - 09/03/21

Doi : 10.1016/j.neurol.2021.01.003

S. Dupont ^a,^b,^c,^⁎ , L. Vercueil ^d
^a Epilepsy and Rehabilitation Unit, Hôpital de la Pitié-Salpêtrière, AP–HP, Paris, France
^b Centre de Recherche de l’Institut du Cerveau et de la Moëlle Épinière (ICM), UMPC-UMR 7225 CNRS-UMRS 975 INSERM, Paris, France
^c Université Paris Sorbonne, Paris, France
^d EFSN, University Grenoble Alpes, Inserm, U1216, CHU Grenoble Alpes, Grenoble Institut Neurosciences (GIN), 38000 Grenoble, France

^⁎Corresponding author at: Unité d’Épilepsie, Hôpital de la Salpêtrière, 47, boulevard de l’Hôpital, 75651 Paris cedex 13, France.Unité d’Épilepsie, Hôpital de la Salpêtrière47, boulevard de l’HôpitalParis cedex 1375651France

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Abstract

Epilepsy is one of the most common chronic disorders affecting women of childbearing age. Unfortunately, many women with epilepsy (WWE) still report not receiving key information about pregnancy. They obviously need information about epilepsy and pregnancy prior to conception with a particular emphasis on effective birth control (i.e. contraception), necessity to plan pregnancy, antiepileptic drugs optimization, and folate supplementation. The risks associated with use of antiepileptic drugs during pregnancy have to be balanced against fetal and maternal risks associated with uncontrolled seizures. This report reviews evidence-based counseling and management strategies concerning maternal and fetal risks associated with seizures, teratogenic risks associated with antiepileptic drug exposure with a special emphasis on developmental and behavioural outcomes of children exposed to intra utero antiepileptic drugs.

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Keywords : Pregnancy, Epilepsy, Counselling, Education

Abbreviations : WWE, AED, NMA