Novel bioactive properties of low-polarity fractions from sea-buckthorn extracts (Elaeagnus rhamnoides (L.) A. Nelson) – (in vitro) - 03/03/21
, R. Kontek a, J. Żuchowski b, A. Stochmal bBienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
| pages | 11 |
| Iconographies | 5 |
| Vidéos | 0 |
| Autres | 0 |
Graphical abstract |
Highlights |
• | Low-polarity fractions from sea-buckthorn exhibit stronger cytotoxicity in cancer cells than the normal ones. |
• | Certain concentrations of low-polarity fractions from sea-buckthorn increase damage of DNA in selected types of cancer cells. |
• | Low polarity fractions from sea-buckthorn induce apoptosis of the selected cancer cell lines. |
Abstract |
Due to the richness of bioactive substances and easy accessibility, sea-buckthorn can be an ingredient of currently popular functional food supporting anti-cancer therapy. Low-polarity fractions from fruit (OL), twigs (GL) and leaves (LL) were investigated. Compared to the previous scientific reports a more detailed analysis of the chemical composition of individual fractions was performed. Cytotoxicity of low-polarity fractions has been investigated and activity compared in human tumor and normal cells cultured in vitro. The genotoxicity and pro-apoptotic properties of low-polarity fractions were also followed on selected cell lines that had proved to be the most sensitive. In the proposed research model being tested, low-polarity fractions act cytotoxically, even 3 times more strongly in cancer cells than normal ones. Measurement of caspase 3/7 activity indicated that cell death occurs through apoptosis. Furthermore, high concentrations of low-polarity fractions have moderate genotoxic properties. Data obtained on the biological properties of low-polarity fractions from sea-buckthorn show that these fractions can potentially support cancer cells elimination. Phytotochemical analysis indicates the key role of the triterpenoids in this process.
Le texte complet de cet article est disponible en PDF.Keywords : Sea-buckthorn, Cytotoxicity, Genotoxicity, Apoptosis, Cancer
Plan
Vol 135
Article 111141- mars 2021 Retour au numéro
Article précédent
- Outer membrane protein a in Acinetobacter baumannii induces autophagy through mTOR signalling pathways in the lung of SD rats
- Dan Zhao, Yumei Li, Chunhong Peng, Jieru Lin, Fuxun Yu, Yichen Zhao, Xiangyan Zhang, Degang Zhao
- PSB 603 – a known selective adenosine A2B receptor antagonist – has anti-inflammatory activity in mice
- Magdalena Kota?ska, Ma?gorzata Szafarz, Kamil Mika, Anna Dziubina, Marek Bednarski, Christa E. Müller, Jacek Sapa, Katarzyna Kie?-Kononowicz
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’achat d’article à l’unité est indisponible à l’heure actuelle.
Déjà abonné à cette revue ?