A comparison of characteristics and outcomes of patients with community-acquired and hospital-acquired COVID-19 in the United Kingdom: An observational study - 27/02/21
, Muhammad Bilal a, 1, Muhammad U. Shahzad a, 1, Alson Rodrigues a, Jehad A. Suliman a, Muhammad Soban a, Shahzeb Mirza a, Nicoleta Lotca a, Mohammed R. Ruslan a, Danyal Memon c, Muhammad A. Arshad d, Kiran Fatima e, Asma Kamran a, Emmanuel E. Egom f, g, Abdul Aziz h
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Abstract |
Background and objectives |
Reports comparing the characteristics of patients and their clinical outcomes between community-acquired (CA) and hospital-acquired (HA) COVID-19 have not yet been reported in the literature. We aimed to characterise and compare clinical, biochemical and haematological features, in addition to clinical outcomes, between these patients.
Methods |
This multi-centre, retrospective, observational study enrolled 488 SARS-CoV-2 positive patients - 339 with CA infection and 149 with HA infection. All patients were admitted to a hospital within the University Hospitals of Morecambe Bay NHS Foundation Trust between March 7th and May 18th, 2020.
Results |
The CA cohort comprised of a significantly younger population, median age 75 years, versus 80 years in the HA cohort (P = 0·0002). Significantly less patients in the HA group experienced fever (P = 0·03) and breathlessness (P < 0·0001). Furthermore, significantly more patients had anaemia and hypoalbuminaemia in the HA group, compared to the CA group (P < 0·0001 for both). Hypertension and a lower median BMI were also significantly more pronounced in the HA cohort (P = 0·03 and P = 0·0001, respectively). The mortality rate was not significantly different between the two cohorts (34% in the CA group and 32% in the HA group, P = 0·64). However, the CA group required significantly greater ICU care (10% versus 3% in the HA group, P = 0·009).
Conclusion |
Hospital-acquired and community-acquired COVID-19 display similar rates of mortality despite significant differences in baseline characteristics of the respective patient populations. Delineation of community- and hospital-acquired COVID-19 in future studies on COVID-19 may allow for more accurate interpretation of results.
Le texte complet de cet article est disponible en PDF.Highlights |
• | COVID-19 depicts a wide spectrum of disease severity. |
• | Poor prognosis is associated with increasing age and co-morbidities. |
• | Community and hospital COVID-19 represent two separate sub-entities of the disease. |
• | This study shows significant differences observed between the two cohorts. |
Keywords : COVID-19, SARS-CoV-2, Hospital-acquired, Community-acquired
Plan
Vol 178
Article 106314- mars 2021 Retour au numéro
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