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Predictive performance of blood urea nitrogen to serum albumin ratio in elderly patients with gastrointestinal bleeding - 24/02/21

Doi : 10.1016/j.ajem.2020.12.022 
Sung Jin Bae, M.D. a, b, Keon Kim, M.D. c, Seong Jong Yun d, Sun Hwa Lee, M.D., Ph.D a,
a Ewha Womans University Mokdong Hospital, Department of Emergency Medicine, College of Medicine, Ewha Womans University, 1071, Anyangcheon-ro, Yangcheon-gu, Seoul, Republic of Korea 
b Chung Ang University College of Medicine, 102, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea 
c Ewha Womans University Seoul Hospital, Department of Emergency Medicine, College of Medicine, Ewha Womans University, 260, Gonghang-daero, Gangseo-gu, Seoul, Republic of Korea 
d G SAM Hospital, Department of Radiology, 591 gunpo-ro, Gunpo-si, Gyeonggi-do, 15839, Republic of Korea 

Corresponding author.

Abstract

Introduction

Acute gastrointestinal (GI) bleeding is one of the most important and the common causes of patients visiting the emergency department. Dehydrated state leads to increased blood urea nitrogen (BUN) and decreased albumin level. Many scoring systems had been developed to predict outcomes for patients with GI bleeding. Among the many scoring systems, the AIMS65 score was a simple and accurate risk assessment scoring tool. Therefore, in this study, we evaluated the prognostic performance of the blood urea nitrogen to serum albumin ratio (B/A ratio) compared to the AIMS65 score tool in elderly patients with GI bleeding.

Material and methods

This was a retrospective cohort study of patients with GI bleeding in our institution from February 2018 through May 2020. Baseline characteristic data were obtained. The data were compared with the prevalence of ICU admission and in-hospital mortality. The B/A ratio and the AIMS65 score as predictors of ICU admission and in-hospital mortality was evaluated using the area under the receiver operating characteristic (AUROC) curve.

Results

In the 596 patients included in the study, of whom 188 (31.5%) were admitted to the ICU and 36 (6.0%) died during hospitalization. Multivariate logistic regression analysis revealed that the B/A ratio was significant predictors of ICU admission and in-hospital mortality. In addition, the B/A ratio was significant higher in ICU admission patients and non-survivors. The AUROC value of the B/A ratio was 0.682 and that of the AIMS65 score was 0.699 for predicting ICU admission. For predicting in-hospital mortality, the AUROC value was 0.770 and 0.763, respectively.

Conclusion

The B/A ratio is as simple and useful tool for predicting outcomes for old aged GI bleeding patients as the AIMS65 score.

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Highlights

Gastrointestinal bleeding (GI bleeding) is one of the most important disease in elderly patients
AIMS65 scoring system contains subjective variable, such as mental status
Dehydrated state leads to increased blood urea nitrogen (BUN) and decreased albumin level
The BUN/Albumin ratio is as simple and useful tool for predicting outcomes as AIMS65 score

Le texte complet de cet article est disponible en PDF.

Keywords : Gastrointestinal hemorrhage, Albumin, Blood urea nitrogen, Mortality, Intensive care units, Emergency departments


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Vol 41

P. 152-157 - mars 2021 Retour au numéro
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