Cardiovascular and All-Cause Mortality Risk by Coronary Artery Calcium Scores and Percentiles Among Older Adult Males and Females - 23/02/21
Abstract |
Background |
Coronary calcium is a marker of coronary atherosclerosis and established predictor of cardiovascular risk in general populations; however, there are limited studies examining its prognostic value among older adults (≥75 years) and even less regarding its utility in older males compared with females. Accordingly, we sought to examine the prognostic significance of both absolute and percentile coronary calcium scores among older adults.
Methods |
The multicenter Coronary Artery Calcium Consortium consists of 66,636 asymptomatic patients without cardiovascular disease. Participants ages ≥75 were included in this study and stratified by sex. Multivariable Cox regression models were constructed to assess cardiovascular and all-cause mortality risk by Agatston coronary calcium scores and percentiles.
Results |
Among 2,474 asymptomatic patients (mean age 79 years, 10.4-year follow-up), prevalence of coronary artery calcium was 92%. For both sexes, but in females more so than males, higher coronary calcium score and percentiles were associated with increased cardiovascular and all-cause mortality risk. Those at the lowest coronary calcium categories (0-9 and <25 percentile) had significantly lower risk of cardiovascular and all-cause mortality relative to the rest of the population. Multivariable analyses of traditional cardiovascular risk factors and coronary artery calcium variables revealed that age and coronary calcium were the strongest independent predictors for adverse outcomes.
Conclusions |
Both coronary artery calcium scores and percentiles are strongly predictive of cardiovascular and all-cause mortality among older adults, with greater risk-stratification among females than males. Both low coronary artery calcium scores 0-9 and <25th percentile define relatively low risk older adults.
Le texte complet de cet article est disponible en PDF.Keywords : Aging, Cardiovascular mortality, Coronary artery calcium, Older adults, Prognosis, Sex differences
Plan
| Funding: NIH Grant L30 HL110027 and Miriam and Sheldon G. Adelson Medical Research Foundation. |
|
| Conflicts of Interest: MJB receives modest grant support from General Electric. KM reports funding from the National Institutes of Health (NIH) outside of the work. FMW, AR, YA, MDM, KN, LJS, JAR, RSB, DSB report none. |
|
| Authorship: All authors had access to the data and a role in writing this manuscript. |
Vol 134 - N° 3
P. 341 - mars 2021 Retour au numéro
Article précédent
- Aspergillus Nodule with Hilar and Mediastinal Lymphadenopathy Mimicking Lung Cancer
- Shusaku Fujimoto, Naohiro Oda, Takahiro Taki, Reo Mitani, Ichiro Takata
- Adherence to Stepped Care for Management of Musculoskeletal Knee Pain Leads to Lower Health Care Utilization, Costs, and Recurrence
- Alessandra N. Garcia, Chad E. Cook, Daniel I. Rhon
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?