Low immune response rate of HIV-infected patients to a single injection of hepatitis A vaccine - 20/02/21
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Highlights |
• | Low response rate of controlled HIV-patients to a single injection of HAV vaccine. |
• | Significantly higher T CD4/CD8 cell ratio among responders. |
• | Serologic control required in case of a single injection vaccination scheme. |
Abstract |
Objectives |
We aimed to evaluate the immune response of HIV-1 positive patients to a single injection of HAV vaccine in a context of vaccine shortage during the 2017 European outbreak.
Methods |
We retrospectively enrolled all HIV-1 positive patients vaccinated by a single injection of HAV vaccine Vaqta 50®. HAV serology was performed before and>30 days after the vaccine injection.
Results |
Among the 73 patients, HIV-1 viral load was≤50 copies/mL in 93.2% of the cases. Medians of CD4 and median ratio of T CD4/CD8 cells were 658/mm3 and 0.9, respectively. A low immune response rate (59.7%) was observed among the patients. Responders had a significantly higher CD4/CD8 cell ratio than non-responders.
Conclusions |
A serologic control should be recommended in this population in the event of a single injection vaccination schedule. During routine follow-up, and prior to any untoward event, physicians should assess the vaccination coverage of HIV-infected patients.
Le texte complet de cet article est disponible en PDF.Keywords : Hepatitis A, HIV infection, Immune response, Vaccine, Hepatitis A antibodies, Disease outbreak
Plan
Vol 51 - N° 1
P. 94-96 - février 2021 Retour au numéro
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