Attainment of the Patient-acceptable Symptom State in 548 patients with rheumatoid arthritis: Influence of demographic factors - 11/02/21
, Eduardo Santos a, c, d, Tore Kristian Kvien e, Maxime Dougados f, Maarten de Wit g, Laure Gossec h, i, 1, José António Pereira da Silva a, b, 1Bienvenue sur EM-consulte, la référence des professionnels de santé.
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Highlights |
• | In Rheumatoid Arthritis (RA) disease activity, pain and emotional well-being were independently associated with being in patient acceptable symptom status (PASS). |
• | Among patients in inflammatory remission, being in PASS was more frequent among older patients and residents in countries with lower Gross Domestic Product per capita. |
• | PASS status is related to many factors beyond disease activity, which deserve careful consideration when devising management strategies. |
Abstract |
Objectives |
To explore the clinical and socio-demographic factors associated with Patient Acceptable Symptom Status (PASS) in Rheumatoid Arthritis (RA).
Methods |
In a post-hoc analyses of a cross-sectional study, RA patients from 11 countries were included. PASS was assessed as acceptable/not acceptable status by the patient. Variables collected included socio-economic (gender, age and country gross domestic product (GDP) per capita) and clinical variables: DAS28-3vESR (28 joint counts and Erythrocyte Sedimentation Rate), the patient-reported Rheumatoid Arthritis Impact of Disease (RAID) score and its seven domains (scored 0 to 10). Patients in PASS or not were compared through univariable tests and factors associated with PASS assessed by multivariable forward conditional logistic regression. A similar analysis was performed in the subgroup patients in DAS28 remission (n=168).
Results |
A total of 548 patients were included: 80.5% female, mean (±SD) age 55.8±12.8years, disease duration 13.6±10.6 years, DAS28 3.6±1.5. Overall, 360 (65.7%) considered themselves to be in PASS. Independent factors positively associated with being in PASS were age>50 years [odds ratio, OR 1.67; (95% confidence Interval: 1.04–2.67)], a lower DAS28 [OR: 1.28 (1.08–1.52)], lower pain [OR:1.45 (1.27–1.64)] and better emotional well-being [OR:1.28 (1.13–1.45)]. Among patients in remission, being in PASS was positively associated with less severe pain [OR: 2.50 (1.79–3.84)], age>50 years [OR 3.30 (1.03 to10.87)] and living in a country of the low GDP category [OR: 5.08; (1.34–19.23)].
Conclusions |
Being in PASS is related to many factors besides disease activity, including age, perceived impact of the disease and national GDP.
Le texte complet de cet article est disponible en PDF.Keywords : Rheumatoid Arthritis, Patient Reported Outcomes, Patient Acceptable Symptom State, Disease Activity, Socio-Demographic Aspects
Plan
Vol 88 - N° 1
Article 105071- janvier 2021 Retour au numéro
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