SARS-CoV-2 infection and its association with thrombosis and ischemic stroke: a review - 03/02/21
Abstract |
This review of current literature provides background to the COVID-19 pandemic, as well as an examination of potential pathophysiologic mechanisms behind development of thrombosis and ischemic stroke related to COVID-19. SARS-CoV-2 infection is well-documented to cause severe pneumonia, however, thrombosis and thrombotic complications, such as ischemic stroke, have also been documented in a variety of patient demographics. SARS-CoV-2 infection is known to cause a significant inflammatory response, as well as invasion of vascular endothelial cells, resulting in endothelial dysfunction. These factors, coupled with imbalance of ACE2 and RAS axis interactions, have been shown to create a prothrombotic environment, favoring thromboembolic events. Ischemic stroke is a severe complication of COVID-19 and may be a presenting symptom in some patients.
Le texte complet de cet article est disponible en PDF.Highlights |
• | SARS-CoV-2 infection precipitates a pro-thrombotic state. |
• | Thrombosis is a complication of COVID-19 and is associated with increased mortality. |
• | Stroke due to COVID-19 is seen in many patient groups and may be a presenting symptom. |
Keywords : Coronavirus, Stroke, Thrombosis, COVID-19
Non-standard Abbreviations and Acronyms : ACE2, ANGII, ANG1–7, SARS-CoV-2, COVID-19, R0, RAS, S-protein
Plan
Vol 40
P. 188-192 - février 2021 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.