Hydroxyurea Exposure in Lactation: a Pharmacokinetics Study (HELPS) - 27/01/21
Doi : 10.1016/j.jpeds.2020.02.002
Russell E. Ware, MD, PhD 1, 2, 3, ⁎ 
, Anu Marahatta, PhD 1, Julie L. Ware, MD, MPH 4, Kathryn McElhinney, BS 1, Min Dong, PhD 3, 5, Alexander A. Vinks, PhD, PharmD 3, 5
, Anu Marahatta, PhD 1, Julie L. Ware, MD, MPH 4, Kathryn McElhinney, BS 1, Min Dong, PhD 3, 5, Alexander A. Vinks, PhD, PharmD 3, 5 1 Division of Hematology, Cincinnati Children's Hospital, Cincinnati, OH
2 Global Health Center, Cincinnati Children's Hospital, Cincinnati, OH
3 University of Cincinnati College of Medicine, Cincinnati, OH
4 Center for Breastfeeding Medicine, Cincinnati Children's Hospital, Cincinnati, OH
5 Division of Clinical Pharmacology, Cincinnati Children's Hospital, Cincinnati, OH
∗Reprint requests: Russell E. Ware, MD, PhD, Division of Hematology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229.Division of HematologyCincinnati Children's Hospital Medical Center3333 Burnet AveCincinnatiOH45229
Abstract |
Lactation is contraindicated for women with sickle cell anemia receiving hydroxyurea therapy, despite sparse pharmacokinetics data. In 16 women who were lactating volunteers, we documented hydroxyurea transferred into breastmilk with a relative infant dosage of 3.4%, which is below the recommended 5%-10% safety threshold. Breastfeeding should be permitted for women taking daily oral hydroxyurea.
Le texte complet de cet article est disponible en PDF.Keywords : hydroxyurea, sickle cell anemia, breastfeeding, pharmacokinetics
Abbreviations : PK, RID, SCA
Plan
| Supported by the Cincinnati Children's Research Foundation. R.W. has received hydroxyurea donations from Bristol-Myers Squibb and Addmedica for use in other clinical trials, and serves on the Advisory Board for Global Blood Therapeutics, Agios, and Nova Laboratories. The authors declare no conflicts of interest. |
© 2020
Elsevier Inc. Tous droits réservés.
Vol 222
P. 236-239 - juillet 2020 Retour au numéro
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