Birth Weight and Weight Changes from Infancy to Early Childhood as Predictors of Body Mass Index in Adolescence - 27/01/21

Doi : 10.1016/j.jpeds.2020.03.048

Katharina Stock, MD ^1,², Rajini Nagrani, PhD ^3,⁴, Nina Gande, MD ¹, Benoit Bernar, MD ^3,⁵, Anna Staudt, MD ¹, Peter Willeit, MD, PhD ^3,⁶, Ralf Geiger, MD ^2,⁷, Michael Knoflach, MD ³, Ursula Kiechl-Kohlendorfer, MD, MSc ^1,^⁎
for The
Early Vascular Aging (EVA) Study Group^∗
List of additional members of the EVA Study Group are listed in Appendix 1 (www.jpeds.com).
Bernhard Winder, MD, Carmen Reiter, Christina Burger, MD, Christoph Hochmayr, MD, Julia Klingenschmid, MD, Julia Marxer, MD, Mandy Asare, Manuela Bock-Bartl, MSc, Martina Kothmayer, Maximilian Bohl, MD, Maximilian Pircher, Sophia Julia Kiechl, MD, Stefan Kiechl, MD

¹ Department of Pediatrics II (Neonatology), Medical University of Innsbruck, Innsbruck, Austria
² Department of Pediatrics III (Cardiology), Medical University of Innsbruck, Innsbruck, Austria
³ Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria
⁴ Department of Epidemiological Methods and Etiological Research, Leibniz Institute for Prevention Research and Epidemiology, Bremen, Germany
⁵ Department of Pediatrics I, Medical University of Innsbruck, Innsbruck, Austria
⁶ Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
⁷ Department of Pediatrics, Hospital of Bruneck, Bruneck, Italy

^∗Reprint requests: Ursula Kiechl-Kohlendorfer, MD, MSc, Department of Pediatrics II (Neonatology), Medical University of Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria.Department of Pediatrics II (Neonatology)Medical University of InnsbruckAnichstrasse 35Innsbruck6020Austria

Abstract

Objective

To assess the time point during infancy and early childhood at which greater than expected weight gain is associated with overweight in adolescence.

Study design

Current height, weight, and body mass index (BMI) were assessed in 1520 adolescents (mean age of boys, 15.52 ± 0.84 years; mean age of girls, 15.37 ± 0.77 years). Information on weight and height trajectories during infancy and early childhood (birth and 6 other time points) was extracted from mother-child booklets. Conditional relative weights were computed to estimate greater or lower than expected weight gain (ie, soft tissue gain at a specific age independent of linear growth), and their association with BMI in adolescence was investigated using linear regression analysis.

Results

The mean BMI in adolescence was 21.77 ± 3.69 in boys and 21.70 ± 3.50 in girls. The proportion of overweight was 14.8% in each group. Overweight adolescents had significantly higher weight z-scores at birth, 1.2 month, 3.3 months, 7.6 months, 1 year, 2 years, and 4 years of age as compared with normal-weight adolescents. There were significant positive associations of weight z-scores and conditional relative weights with adolescent BMI at all ages except birth, which were strongest after the first year of life. In a majority of overweight adolescents, overweight had manifested within the first 4 years of life.

Conclusions

Greater than expected weigh gain at any time in the first years of life is associated with an increased BMI in adolescence. The effect is strongest after the first year.

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Keywords : conditional relative weight, overweight, early childhood, adolescence, early vascular aging study

Abbreviations : BMI, EVA

Plan

Methods

Results

Discussion

Early Vascular Ageing (EVA) Tyrol is financially supported by the excellence initiative (Competence Centers for Excellent Technologies - COMET) of the Austrian Research Promotion Agency FFG: “Research Center of Excellence in Vascular Ageing, VASCage” (No. 868624) funded by BMVIT, BMWFW, Wirtschaftsagentur Wien, and Standortagentur Tirol. The funders had no role in study design, data collection, analysis, decision to publish, or preparation of the manuscript. The authors declare no conflicts of interest.

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Vol 222

P. 120 - juillet 2020 Retour au numéro

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Birth Weight and Weight Changes from Infancy to Early Childhood as Predictors of Body Mass Index in Adolescence - 27/01/21

Abstract

Objective

Study design

Results

Conclusions

Plan

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