Small Cell Carcinoma of Ovary, Hypercalcemic Type: Cytologic, Histopathologic, and Immunohistochemical Landscapes of a Rare Case - 21/01/21
, Prashant Chhabra, MD 2, Nitin James Peters, MS, MCh 3, Deepak Bansal, MD 2, Radhika Srinivasan, MD, PhD 1, Nandita Kakkar, MD 4Abstract |
Background |
Small cell carcinoma of ovary, hypercalcemia type (SCCOHT), also known as the malignant rhabdoid tumor of the ovary, is a rare and highly aggressive malignancy affecting younger women. The pathogenesis involves mutations in SWI/SNF-related, matrix-associated, actin-dependent regulator chromatin group A4 (SMARCA4)/Brahma-related gene 1 (BRG1) and/or SWI/SNF-related, matrix-associated, actin-dependent regulator chromatin group A2 (SMARCA2)/Brahma homolog (BRM).
Case |
A 10-year-old girl presented with lower abdominal pain and a mass for the past 2 weeks. She underwent ultrasound-guided fine needle aspiration and core needle biopsy from the pelvic mass followed by surgery. On the basis of the characteristic morphologic and immunohistochemical features, a diagnosis of SCCOHT was rendered. Chemotherapy was started, however, she succumbed to the disease.
Le texte complet de cet article est disponible en PDF.Key Words : Small-cell carcinoma ovary, Small-cell carcinoma ovary hypercalcemic type, Cytology, Histopathology, Immunohistochemistry
Plan
| The authors indicate no conflicts of interest. |
Vol 34 - N° 1
P. 98-102 - février 2021 Retour au numéro
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